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UniProtKB/Swiss-Prot entry Q71ZD6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH2_LISMF
Primary accession number Q71ZD6
Secondary accession numbers None
Integrated into Swiss-Prot on June 7, 2005
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 35)
Name and origin of the protein
Protein name L-lactate dehydrogenase 2
Synonyms L-LDH 2
EC 1.1.1.27
Gene name
Name: ldh2
OrderedLocusNames: LMOf2365_1553
From
Listeria monocytogenes serotype 4b (strain F2365) [TaxID: 265669] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/nar/gkh562; PubMed=15115801 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O., Luchansky J.B., Fraser C.M.;
"Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species.";
Nucleic Acids Res. 32:2386-2395(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017262; AAT04328.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_014151.1; -.
3D structure databases
HSSP P16115; 1A5Z. [HSSP ENTRY / PDB]
ModBase Q71ZD6.
Enzyme and pathway databases
BioCyc LMON265669:LMOF2365_1553-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q71ZD6.
Genome annotation databases
GeneID 2799266; -.
GenomeReviews AE017262_GR; LMOf2365_1553.
KEGG lmf:LMOf2365_1553; -.
TIGR LMOf2365_1553; -.
Phylogenomic databases
HOGENOM Q71ZD6; -.
Other
ProtoNet Q71ZD6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   311  311     L-lactate dehydrogenase 2. PRO_0000168364
NP_BIND   12    40  29     NAD (By similarity). 
ACT_SITE   177   177        Proton acceptor. 
BINDING   90    90        Substrate (By similarity). 
BINDING   122   122        NAD or substrate (By similarity). 
BINDING   153   153        Substrate (By similarity). 
BINDING   230   230        Substrate (By similarity). 
Sequence information
Length: 311 AA [This is the length of the unprocessed precursor] Molecular weight: 33783 Da [This is the MW of the unprocessed precursor] CRC64: 1B288BDBDC01DC07 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKPRKVMIIG AGNVGTAAAH AFVNQKFVEE LILVDLNKER VEGNRKDLAD AAAFMPGKMD 

        70         80         90        100        110        120 
ITVRDASDCA DVDIAVITVT AGPLKEGQTR LDELRSTSRI VSSIVPEMMK GGFNGIFLIA 

       130        140        150        160        170        180 
TNPCDIITYQ VWKLSGLPRE RVLGTGVWLD TTRLRRLLAE KLDIAAQSID AFILGEHGDS 

       190        200        210        220        230        240 
QFPVWSHSSI YGKPVNEYSV EKLGEALDLK QIGETARDTG FEIYHQKGCT EYGIGGTIVE 

       250        260        270        280        290        300 
ICRHIFSGSQ RALTVSCVLD GEYGESGLAI GVPAVLSQNG VKEIISLKLD EKEKEAFANS 

       310 
VAVIKKSIQS I
Q71ZD6 in FASTA format

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