[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=cv. Nipponbare; The international rice genome sequencing project (IRGSP) consortium; "Oryza sativa nipponbare chromosome 8 genomic DNA sequence."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=cv. Nipponbare; DOI=10.1126/science.1081288; PubMed=12869764 [NCBI, ExPASy, EBI, Israel, Japan] The rice full-length cDNA consortium; "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."; Science 301:376-379(2003).
[3]	NOMENCLATURE. DOI=10.1007/s00239-004-2666-z; PubMed=15599508 [NCBI, ExPASy, EBI, Israel, Japan] Teixeira F.K., Menezes-Benavente L., Margis R., Margis-Pinheiro M.; "Analysis of the molecular evolutionary history of the ascorbate peroxidase gene family: inferences from the rice genome."; J. Mol. Evol. 59:761-770(2004).

Comments

FUNCTION: Plays a key role in hydrogen peroxide removal (By similarity).
CATALYTIC ACTIVITY: L-ascorbate + H₂O₂ = dehydroascorbate + 2 H₂O.
COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group (By similarity).
COFACTOR: Binds 1 potassium or calcium ion per subunit (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the peroxidase family. Ascorbate peroxidase subfamily.
CAUTION: According to Ref.3, it may be peroxisomal. There is however no experimental evidence to prove this.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP003912; BAD08951.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK070842; -; NOT_ANNOTATED_CDS; mRNA.	[EMBL / GenBank / DDBJ]

RefSeq

NP_001062439.1; -.

UniGene

Os.10609

3D structure databases

HSSP

P48534; 1APX. [HSSP ENTRY / PDB]

ModBase

Q6ZJJ1.

Protein family/group databases

PeroxiBase

1868; OsAPx04.

Organism-specific databases

Gramene

Q6ZJJ1; -.

Family and domain databases

InterPro

IPR002207; Asc_perxdse.
IPR002016; Haem_peroxidase_pln/fun/bac.
Graphical view of domain structure.

Pfam

PF00141; peroxidase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00459; ASPEROXIDASE.
PR00458; PEROXIDASE.

PROSITE

PS00435; PEROXIDASE_1; 1.
PS00436; PEROXIDASE_2; 1.
PS50873; PEROXIDASE_4; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q6ZJJ1.

Genome annotation databases

GeneID

4346247; -.

KEGG

osa:4346247; -.

Other

ProtoNet

Q6ZJJ1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Calcium; Heme; Hydrogen peroxide; Iron; Membrane; Metal-binding; Oxidoreductase; Peroxidase; Potassium; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 291`	`291`	`Probable L-ascorbate peroxidase 4.`	`PRO_0000055596`
`TRANSMEM`	`263 283`	`21`	`Potential.`
`ACT_SITE`	`40 40`		`Proton acceptor (By similarity).`
`METAL`	`160 160`		`Iron (heme axial ligand) (By similarity).`
`METAL`	`161 161`		`Potassium or calcium (By similarity).`
`METAL`	`177 177`		`Potassium or calcium (By similarity).`
`METAL`	`184 184`		`Potassium or calcium (By similarity).`
`SITE`	`36 36`	`1`	`Transition state stabilizer (By similarity).`

Sequence information

Length: 291 AA [This is the length of the unprocessed precursor]

Molecular weight: 31738 Da [This is the MW of the unprocessed precursor]

CRC64: 5B605C442EB57807 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAPVVDAEY LRQVDRARRH LRALISSKGC APIMLRLAWH DAGTYDVNTK TGGANGSIRY 

        70         80         90        100        110        120 
EEEYTHGSNA GLKIAIDLLE PIKAKSPKIT YADLYQLAGV VAVEVTGGPT VEFIPGRRDS 

       130        140        150        160        170        180 
SVCPREGRLP DAKKGALHLR DIFYRMGLSD KDIVALSGGH TLGRAHPERS GFEGAWTQEP 

       190        200        210        220        230        240 
LKFDNSYFLE LLKGESEGLL KLPTDKALLE DPSFRRYVDL YARDEDTFFK DYAESHKKLS 

       250        260        270        280        290 
ELGFTPRSSG PASTKSDLST GAVLAQSAVG VAVAAAVVIV SYLYEASKKS K

Q6ZJJ1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools