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UniProtKB/Swiss-Prot entry Q6UWM7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LCTL_HUMAN
Primary accession number Q6UWM7
Secondary accession numbers None
Integrated into Swiss-Prot on October 11, 2005
Sequence was last modified on October 11, 2005 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 46)
Name and origin of the protein
Protein name Lactase-like protein [Precursor]
Synonym Klotho/lactase-phlorizin hydrolase-related protein
Gene name
Name: LCTL
Synonyms: KLPH
ORFNames: UNQ3022/PRO9820
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[2]
 PROTEIN SEQUENCE OF 22-36.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY358729; AAQ89091.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_997221.2; -.
UniGene Hs.680983
3D structure databases
ModBase Q6UWM7.
PTM databases
PhosphoSite Q6UWM7; -.
Organism-specific databases
HGNC HGNC:15583; LCTL.
GenAtlas LCTL.
PharmGKB PA142671560; -.
GeneCards Q6UWM7.
Gene expression databases
ArrayExpress Q6UWM7; -.
CleanEx HS_LCTL; -.
GermOnline ENSG00000188501; Homo sapiens.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0043169; Molecular function: cation binding (inferred from electronic annotation from InterPro).
GO:0004553; Molecular function: hydrolase activity, hydrolyzing O-glycosyl compounds (inferred from electronic annotation from InterPro).
GO:0005975; Biological process: carbohydrate metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001360; Glyco_hydro_1.
IPR013781; Glyco_hydro_sub_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.80; Glyco_hydro_cat; 1.
PANTHER PTHR10353; Glyco_hydro_1; 1.
Pfam PF00232; Glyco_hydro_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00131; GLHYDRLASE1.
PROSITE PS00572; GLYCOSYL_HYDROL_F1_1; 1.
PS00653; GLYCOSYL_HYDROL_F1_2; 1.
ProtoNet Q6UWM7.
Genome annotation databases
Ensembl ENSG00000188501; Homo sapiens. [Contig view]
GeneID 197021; -.
KEGG hsa:197021; -.
Phylogenomic databases
HOGENOM Q6UWM7; -.
HOVERGEN Q6UWM7; -.
Other
NextBio 89604; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Membrane; Polymorphism; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21      
CHAIN   22   567  546     Lactase-like protein. PRO_0000042251
TOPO_DOM   23   541  519     Extracellular (Potential). 
TRANSMEM   542   562  21     Potential. 
TOPO_DOM   563   567  5     Cytoplasmic (Potential). 
CARBOHYD   80    80        N-linked (GlcNAc...) (Potential). 
CARBOHYD   171   171        N-linked (GlcNAc...) (Potential). 
CARBOHYD   245   245        N-linked (GlcNAc...) (Potential). 
VARIANT   240   240  1     A -> T (in dbSNP:rs1030986 [NCBI]). VAR_023586 
Sequence information
Length: 567 AA [This is the length of the unprocessed precursor] Molecular weight: 65088 Da [This is the MW of the unprocessed precursor] CRC64: DA840A92E933C0AE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKPVWVATLL WMLLLVPRLG AARKGSPEEA SFYYGTFPLG FSWGVGSSAY QTEGAWDQDG 

        70         80         90        100        110        120 
KGPSIWDVFT HSGKGKVLGN ETADVACDGY YKVQEDIILL RELHVNHYRF SLSWPRLLPT 

       130        140        150        160        170        180 
GIRAEQVNKK GIEFYSDLID ALLSSNITPI VTLHHWDLPQ LLQVKYGGWQ NVSMANYFRD 

       190        200        210        220        230        240 
YANLCFEAFG DRVKHWITFS DPRAMAEKGY ETGHHAPGLK LRGTGLYKAA HHIIKAHAKA 

       250        260        270        280        290        300 
WHSYNTTWRS KQQGLVGISL NCDWGEPVDI SNPKDLEAAE RYLQFCLGWF ANPIYAGDYP 

       310        320        330        340        350        360 
QVMKDYIGRK SAEQGLEMSR LPVFSLQEKS YIKGTSDFLG LGHFTTRYIT ERNYPSRQGP 

       370        380        390        400        410        420 
SYQNDRDLIE LVDPNWPDLG SKWLYSVPWG FRRLLNFAQT QYGDPPIYVM ENGASQKFHC 

       430        440        450        460        470        480 
TQLCDEWRIQ YLKGYINEML KAIKDGANIK GYTSWSLLDK FEWEKGYSDR YGFYYVEFND 

       490        500        510        520        530        540 
RNKPRYPKAS VQYYKKIIIA NGFPNPREVE SWYLKALETC SINNQMLAAE PLLSHMQMVT 

       550        560 
EIVVPTVCSL CVLITAVLLM LLLRRQS
Q6UWM7 in FASTA format

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