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UniProtKB/Swiss-Prot entry Q6TGZ5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HPPD_DANRE
Primary accession number Q6TGZ5
Secondary accession numbers None
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 31)
Name and origin of the protein
Protein name 4-hydroxyphenylpyruvate dioxygenase
Synonyms EC 1.13.11.27
4-hydroxyphenylpyruvic acid oxidase
HPPDase
4HPPD
HPD
Gene name
Name: hpd
ORFNames: zgc:56326
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney marrow;
DOI=10.1073/pnas.0407241101; PubMed=15520368 [NCBI, ExPASy, EBI, Israel, Japan]
Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X., Look A.T., Chen Z.;
"Hematopoietic gene expression profile in zebrafish kidney marrow.";
Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY398361; AAQ97794.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Dr.77434
3D structure databases
SMR Q6TGZ5; 8-367.
ModBase Q6TGZ5.
Organism-specific databases
ZFIN ZDB-GENE-040426-986; zgc:56326.
Gene expression databases
ArrayExpress Q6TGZ5; -.
Family and domain databases
InterPro IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.
PANTHER PTHR11959; HPP_dOase; 1.
Pfam PF00903; Glyoxalase; 2.
Pfam graphical view of domain structure.
PIRSF PIRSF009283; HPP_dOase; 1.
TIGRFAMs TIGR01263; 4HPPD; 1.
BLOCKS Q6TGZ5.
Genome annotation databases
Ensembl ENSDARG00000018351; Danio rerio. [Contig view]
Phylogenomic databases
HOGENOM Q6TGZ5; -.
HOVERGEN Q6TGZ5; -.
Other
ProtoNet Q6TGZ5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   397  397     4-hydroxyphenylpyruvate dioxygenase. PRO_0000088392
METAL   184   184        Iron (By similarity). 
METAL   267   267        Iron (By similarity). 
METAL   350   350        Iron (By similarity). 
Sequence information
Length: 397 AA [This is the length of the unprocessed precursor] Molecular weight: 45211 Da [This is the MW of the unprocessed precursor] CRC64: E689B499A97C8C33 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTSYTDKGEK PERGKFLNFH HIKFWVGNAK QAAVFYCDKF GFEPLAYKGL ETGSREVVSH 

        70         80         90        100        110        120 
AVRQDKIIFV FESALNPGNE EMGEHMIKHG DGVKDVAFLV EDCDFLVKKA KERGAAVLKE 

       130        140        150        160        170        180 
PWVEQDAGGK VKYAIVQTYG DTTHTFVEYL GPYKGLFLPG YKEPLFRDPL LPKLPSGHLS 

       190        200        210        220        230        240 
FIDHIVGNQP DDEMVPVSDW YQKCLLFHRF WSIDDKQIHT EYSALRSIVV TNYEETIKMP 

       250        260        270        280        290        300 
INEPAMGKKK SQIQEYIDYN GGPGVQHIAL NTSNIIQAIV NLRARGLEFL SAPDNYYESL 

       310        320        330        340        350        360 
REKLKTAKIK VKEDLKTLQE LKILVDFDDK GYLLQIFTKP VQDRPTLFLE VIQRNNHFGF 

       370        380        390 
GAGNFKSLFE AIEKDQDARG NLTVLTAQNQ SVSKAFQ 

Q6TGZ5 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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