[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Kidney; NIH - Xenopus Gene Collection (XGC) project; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate (Probable).
CATALYTIC ACTIVITY: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2 .
SIMILARITY: Belongs to the proline oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC059998; AAH59998.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001083128.1; -.

UniGene

Xl.34459

3D structure databases

ModBase

Q6PAY6.

Organism-specific databases

Xenbase

XB-FEAT-5784813; prodh2.

Ontologies

GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002872; Proline_DHase.
IPR015659; Proline_oxidase.
Graphical view of domain structure.

PANTHER

PTHR13914; Proline_oxidase; 1.

Pfam

PF01619; Pro_dh; 1.
Pfam graphical view of domain structure.

Genome annotation databases

GeneID

398760; -.

KEGG

xla:398760; -.

Phylogenomic databases

HOVERGEN

Q6PAY6; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Flavoprotein; Oxidoreductase; Proline metabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 466`	`466`		`Probable proline dehydrogenase 2.`	`PRO_0000308626`

Sequence information

Length: 466 AA [This is the length of the unprocessed precursor]

Molecular weight: 52329 Da [This is the MW of the unprocessed precursor]

CRC64: 873A4E7B7B336E99 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRLLGRYLRL GSPRLCSRVW PTLPPSCSPH STAAAAQAQG ALSFSDGGVF KLKSSWEVAR 

        70         80         90        100        110        120 
GLLIFRMCSF PSLVKHSEKM LSVSRRLLGR RLFEWGMKGS VYGQFVAGET LPEIRVCVDR 

       130        140        150        160        170        180 
LRQLGIHPML AVPIEEDLGQ AKSGERWYEQ NESIMLDCVD LSAAGGDRPM MQLKITALMS 

       190        200        210        220        230        240 
AELCKLLSVH LSHPSNGPQL CPRSIVSIME GKESAFSFLS EGENSHLRNS VRRLSRIAKH 

       250        260        270        280        290        300 
ATANRVRVLV DAEYTYMNPA LSLVTMAMMS QCNQSEPWIW NTYQCYLKDS FSLLSLDLDT 

       310        320        330        340        350        360 
ARSLGLCFGV KLVRGAYMDK ERKLSKQKGY ADPIQHDWEA TNRSYQRSLD KMLDLIGQNG 

       370        380        390        400        410        420 
QRHNLIVASH NEESVLHAVT RMAELGIDKG SGSVSFGQLL GMCDHVSLTL GQAGYLVYKS 

       430        440        450        460 
LPYGSVDSVL PYLIRRAQEN QSVLQGIRKE RDLLRRELKR RLFNQR

Q6PAY6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools