[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Kidney; NIH - Xenopus Gene Collection (XGC) project; Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O₂ = 2-amino-3-carboxymuconate semialdehyde.
COFACTOR: Fe(2+) ion (By similarity).
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 3/3 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the 3-HAO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC061663; AAH61663.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001083573.1; -.

UniGene

Xl.34491

3D structure databases

ModBase

Q6P7I0.

Family and domain databases

InterPro

IPR010329; 3hydroanth_dOase.
IPR016700; 3hydroanth_dOase_met.
Graphical view of domain structure.

Pfam

PF06052; 3-HAO; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF017681; 3hydroanth_dOase_animal; 1.

TIGRFAMs

TIGR03037; anthran_nbaC; 1.

BLOCKS

Q6P7I0.

Genome annotation databases

GeneID

398998; -.

KEGG

xla:398998; -.

Phylogenomic databases

HOVERGEN

Q6P7I0; -.

Other

ProtoNet

Q6P7I0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 282`	`282`	`3-hydroxyanthranilate 3,4-dioxygenase.`	`PRO_0000245467`
`METAL`	`47 47`		`Iron (catalytic) (By similarity).`
`METAL`	`53 53`		`Iron (catalytic) (By similarity).`
`METAL`	`91 91`		`Iron (catalytic) (By similarity).`
`BINDING`	`43 43`		`Dioxygen (By similarity).`
`BINDING`	`53 53`		`Substrate (By similarity).`
`BINDING`	`95 95`		`Substrate (By similarity).`
`BINDING`	`105 105`		`Substrate (By similarity).`

Sequence information

Length: 282 AA [This is the length of the unprocessed precursor]

Molecular weight: 32450 Da [This is the MW of the unprocessed precursor]

CRC64: BF4A6DA45A9BF420 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAMAINVKKW IEENTEYFLP PVCNKLMHNQ QLKVMFVGGP NQRKDYHIEE GEELFYQVEG 

        70         80         90        100        110        120 
DMCLKIVENG KHKDVHIKQG EMFLLPGRIP HSPQRYADTV GLVFERRRLD TEKDGLRFYV 

       130        140        150        160        170        180 
EGSPEVLFEQ WFYCEDLGTQ LAPIMKEFFS SKQYKSGKPD PDQPKAKMPF CLSTEQVMEP 

       190        200        210        220        230        240 
FSFQHWLNKH RLEIIQKKCV SLFGDDHETK AVIYGGGESK QSKAQTDVWI WQLEGTSHVT 

       250        260        270        280 
LGNEVLKLGS GDSLLVPEET LFSWTREDGS IALSTSQVPL PM

Q6P7I0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools