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UniProtKB/Swiss-Prot entry Q6P1G2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name JHD1B_MOUSE
Primary accession number Q6P1G2
Secondary accession numbers Q3V396 Q6PFD0 Q6ZPE8 Q9CSF7 Q9QZN6
Integrated into Swiss-Prot on August 16, 2004
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 52)
Name and origin of the protein
Protein name JmjC domain-containing histone demethylation protein 1B
Synonyms EC 1.14.11.27
[Histone-H3]-lysine-36 demethylase 1B
F-box and leucine-rich repeat protein 10
F-box/LRR-repeat protein 10
F-box protein FBL10
Gene name
Name: Fbxl10
Synonyms: Fbl10, Jhdm1b, Kiaa3014
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
STRAIN=C57BL/6J;
TISSUE=Cerebellum, and Embryo;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6;
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-1309 (ISOFORM 1).
TISSUE=Brain;
DOI=10.1093/dnares/10.4.167; PubMed=14621295 [NCBI, ExPASy, EBI, Israel, Japan]
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.;
"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.";
DNA Res. 10:167-180(2003).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1011-1309 (ISOFORMS 1/2).
DOI=10.1016/S0960-9822(00)80021-4; PubMed=10531037 [NCBI, ExPASy, EBI, Israel, Japan]
Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.;
"A family of mammalian F-box proteins.";
Curr. Biol. 9:1180-1182(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK012952; BAB28568.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK043352; BAE20639.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC057622; AAH57622.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC065090; AAH65090.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK129479; BAC98289.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF176524; AAF09133.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001003953.1; -.
NP_001005866.1; -.
NP_038938.1; -.
UniGene Mm.86406
3D structure databases
SMR Q6P1G2; 35-361.
ModBase Q6P1G2.
Protein-protein interaction databases
IntAct Q6P1G2; -.
PTM databases
PhosphoSite Q6P1G2; -.
Organism-specific databases
MGI MGI:1354737; Fbxl10.
Gene expression databases
CleanEx MM_FBXL10; -.
GermOnline ENSMUSG00000029475; Mus musculus.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR001810; F-box.
IPR001611; LRR.
IPR013129; TF_JmjC.
IPR003347; TF_JmjC_AAH.
IPR002857; Znf_CXXC.
IPR001965; Znf_PHD.
Graphical view of domain structure.
Pfam PF00646; F-box; 1.
PF02373; JmjC; 1.
PF00560; LRR_1; 1.
PF02008; zf-CXXC; 1.
Pfam graphical view of domain structure.
SMART SM00256; FBOX; 1.
SM00558; JmjC; 1.
SM00249; PHD; 1.
SMART graphical view of domain structure.
PROSITE PS50181; FBOX; FALSE_NEG.
PS51184; JMJC; 1.
PS51058; ZF_CXXC; 1.
PS01359; ZF_PHD_1; FALSE_NEG.
PS50016; ZF_PHD_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q6P1G2.
Genome annotation databases
Ensembl ENSMUSG00000029475; Mus musculus. [Contig view]
GeneID 30841; -.
KEGG mmu:30841; -.
Phylogenomic databases
HOGENOM Q6P1G2; -.
HOVERGEN Q6P1G2; -.
Other
SOURCE Fbxl10; Mus musculus.
ROUGE KIAA3014.
ProtoNet Q6P1G2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Chromatin regulator; Coiled coil; Dioxygenase; Iron; Leucine-rich repeat; Metal-binding; Nucleus; Oxidoreductase; Phosphoprotein; Repeat; Transcription; Transcription regulation; Ubl conjugation pathway; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1309  1309     JmjC domain-containing histone demethylation protein 1B. PRO_0000119854
DOMAIN   147    315  169     JmjC. 
DOMAIN   1032   1078  47     F-box. 
REPEAT   1121   1144  24     LRR 1. 
REPEAT   1185   1208  24     LRR 2. 
REPEAT   1242   1266  25     LRR 3. 
REPEAT   1267   1309  43     LRR 4. 
ZN_FING   579    625  47     CXXC-type. 
ZN_FING   632    698  67     PHD-type. 
COILED   916    944  29     Potential. 
COMPBIAS   378    403  26     Glu-rich. 
METAL   211    211        Iron (catalytic) (By similarity). 
METAL   213    213        Iron (catalytic) (By similarity). 
METAL   283    283        Iron (catalytic) (By similarity). 
BINDING   208    208        Substrate (By similarity). 
BINDING   228    228        Substrate (By similarity). 
MOD_RES   192    192        Phosphotyrosine (By similarity). 
MOD_RES   447    447        Phosphoserine (By similarity). 
MOD_RES   470    470        Phosphoserine (By similarity). 
VAR_SEQ   1    533        Missing (in isoform 2). VSP_011342
VAR_SEQ   2   1196        Missing (in isoform 4). VSP_019003
VAR_SEQ   534    551        TLAITGVPVVSWPKKTAK -> MAMSVSAEDDDYESEPDQ (in isoform 2). VSP_011343
VAR_SEQ   627    656        PVLPHTAVCLVCGEAGKEDTVEEEEGKFNL -> VSAQKAQAGLMQGLPAICPALGLLCGMGEV (in isoform 3). VSP_017477
VAR_SEQ   657   1309        Missing (in isoform 3). VSP_017478
CONFLICT   461    461        T -> M (in Ref. 3; BAC98289). 
Sequence information
Length: 1309 AA [This is the length of the unprocessed precursor] Molecular weight: 149733 Da [This is the MW of the unprocessed precursor] CRC64: 5BD203C3535C4D88 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEAEKDSGRR LRAIDRQRYD ENEDLSDVEE IVSVRGFSLE EKLRSQLYQG DFVHAMEGKD 

        70         80         90        100        110        120 
FNYEYVQREA LRVPLVFRDK DGLGIKMPDP DFTVRDVKLL VGSRRLVDVM DVNTQKGTEM 

       130        140        150        160        170        180 
SMSQFVRYYE TPEAQRDKLY NVISLEFSHT KLEHLVKRPT VVDLVDWVDN MWPQHLKEKQ 

       190        200        210        220        230        240 
TEATNALAEM KYPKVKKYCL MSVKGCFTDF HIDFGGTSVW YHVFRGGKIF WLIPPTLHNL 

       250        260        270        280        290        300 
ALYEEWVLSG KQSDIFLGDR VERCQRIELK QGYTFFIPSG WIHAVYTPVD SLVFGGNILH 

       310        320        330        340        350        360 
SFNVPMQLRI YEIEDRTRVQ PKFRYPFYYE MCWYVLERYV YCVTQRSYLT QEYQRELMLI 

       370        380        390        400        410        420 
DAPRKTSVDG FSSDSWLDME EESCEQQPQE EEEEEEDKEE EGDGADKTPK PPTDDPTSPT 

       430        440        450        460        470        480 
STPPEDQDST GKKPKAPAIR FLKRTLSNES EESVKSTSMP TDDPKTPTGS PATEVSTKWT 

       490        500        510        520        530        540 
HLTEFELKGL KALVEKLESL PENKKCVPEG IEDPQALLEG VKNVLKEHVD DDPTLAITGV 

       550        560        570        580        590        600 
PVVSWPKKTA KNRVVGRPKG KLGPASAVKL AANRTTAGAR RRRTRCRKCE ACLRTECGEC 

       610        620        630        640        650        660 
HFCKDMKKFG GPGRMKQSCI MRQCIAPVLP HTAVCLVCGE AGKEDTVEEE EGKFNLMLME 

       670        680        690        700        710        720 
CSICNEIIHP GCLKIKESEG VVNDELPNCW ECPKCNHAGK TGKQKRGPGF KYASNLPGSL 

       730        740        750        760        770        780 
LKEQKMNRDN KEGQEPAKRR SECEEAPRRR SDEHPKKVPA DGILRRKSDD VHLRRKRKYE 

       790        800        810        820        830        840 
KPQELSGRKR ASSLQTSPGS SSHLSPRPPL GSSLSPWWRS SLTYFQQQLK PGKEDKLFRK 

       850        860        870        880        890        900 
KRRSWKNAED RLSLANKPLR RFKQEPEDDL PEAPPKTRES DQSRSSSPTA GPSTEGAEGP 

       910        920        930        940        950        960 
EEKKKVKMRR KRRLVNKELS KELSKELNHE IQKTESTLAH ESQQPIKSEP ESENDEPKRP 

       970        980        990       1000       1010       1020 
LSHCERPHRF SKGLNGTPRE LRHSLGPGLR SPPRVMSRPP PSASPPKCIQ MERHVIRPPP 

      1030       1040       1050       1060       1070       1080 
ISPPPDSLPL DDGAAHVMHR EVWMAVFSYL SHRDLCVCMR VCRTWNRWCC DKRLWTRIDL 

      1090       1100       1110       1120       1130       1140 
NRCKSITPLM LSGIIRRQPV SLDLSWTNIS KKQLSWLINR LPGLRDLVLS GCSWIAVSAL 

      1150       1160       1170       1180       1190       1200 
CSSSCPLLRT LDVQWVEGLK DAQMRDLLSP PTDNRPGQMD NRSKLRNIVE LRLAGLDITD 

      1210       1220       1230       1240       1250       1260 
VSLRLIIRHM PLLSKLQLSY CNHINDQSIN LLTAVGTTTR DSLTEVNLSD CNKVTDLCLS 

      1270       1280       1290       1300 
FFKRCGNICH IDLRYCKQVT KEGCEQFIAE MSVSVQFGQV EEKLLQKLS 

Q6P1G2 in FASTA format

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