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UniProtKB/Swiss-Prot entry Q6NYG8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DPYD_DANRE
Primary accession number Q6NYG8
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Dihydropyrimidine dehydrogenase [NADP+]
Synonyms DHPDHase
DPD
EC 1.3.1.2
Dihydrouracil dehydrogenase
Dihydrothymine dehydrogenase
Gene name
Name: dpyd
ORFNames: zgc:77205
From
Danio rerio (Zebrafish) (Brachydanio rerio) [TaxID: 7955] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC066602; AAH66602.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_998058.1; -.
UniGene Dr.79932
3D structure databases
SMR Q6NYG8; 2-1016.
ModBase Q6NYG8.
Organism-specific databases
ZFIN ZDB-GENE-040426-2459; dpyd.
Gene expression databases
ArrayExpress Q6NYG8; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0017113; Molecular function: dihydropyrimidine dehydrogenase (NADP+) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0006214; Biological process: thymidine catabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006212; Biological process: uracil catabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR000759; Adrndx_reductase.
IPR013785; Aldolase_TIM.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR012285; Fum_reductase_C.
IPR016040; NAD(P)-bd.
IPR001100; Pyr_nuc-diS_OxRdtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01180; DHO_dh; 1.
PF00037; Fer4; 2.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00411; PNDRDTASEI.
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 3.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q6NYG8.
Genome annotation databases
Ensembl ENSDARG00000010267; Danio rerio. [Contig view]
GeneID 405829; -.
KEGG dre:405829; -.
Phylogenomic databases
HOGENOM Q6NYG8; -.
HOVERGEN Q6NYG8; -.
Other
ProtoNet Q6NYG8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Cytoplasm; FAD; Flavoprotein; FMN; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1022  1022     Dihydropyrimidine dehydrogenase [NADP+]. PRO_0000327504
DOMAIN   69    100  32     4Fe-4S ferredoxin-type 1. 
DOMAIN   943    975  33     4Fe-4S ferredoxin-type 2. 
DOMAIN   976   1006  31     4Fe-4S ferredoxin-type 3. 
METAL   952    952        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   955    955        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   958    958        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   962    962        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   985    985        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   988    988        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   991    991        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   995    995        Iron-sulfur 2 (4Fe-4S) (Potential). 
Sequence information
Length: 1022 AA [This is the length of the unprocessed precursor] Molecular weight: 111004 Da [This is the MW of the unprocessed precursor] CRC64: 8A8983492F936654 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATMLSKELQ DIESILALNP RVKSHANVHS TASKKNEKKH WKRNPERSCD SCVNLENNFD 

        70         80         90        100        110        120 
DIKHTTLSER GALREALRCL KCADAPCQKS CPTNLDIKSF ITSISNKNYY GAAKAILSDN 

       130        140        150        160        170        180 
PLGLTCGMVC PTSDLCVGGC NLYASEEGPI NIGGLQQFAT EVFSKMGIPQ IRNPELPTAD 

       190        200        210        220        230        240 
NMPKSFHTRI ALIGCGPASI SCASFLARLG YDNITIFEKQ KYIGGLSTSE IPQFRLPYEV 

       250        260        270        280        290        300 
VQFEIDLMKD LGVKVVLEKG LGQNGLTLTS LKEEGYQVVY IGIGLPQANR DKIFEGLTTE 

       310        320        330        340        350        360 
QGFYTSKDFL PLVAKASKIG MCNCRSQLPK LHGNVIVLGA GDTAFDCATS ALRCGARRVF 

       370        380        390        400        410        420 
VVFRKGFTNI RAVPEEMEAA KEEKCEFLPF LSPHEVIKKN GRVSGLRFCR TEQQDDGTWI 

       430        440        450        460        470        480 
VDEEQIVHLK ADFIISAFGS MLNDPAVTKA LDPIKLNRWG TPEVNSETMQ TTEPWVFAGG 

       490        500        510        520        530        540 
DIAGFANTTV ESVNDGKQAS WHIHKYIQSL HGNTISATPR LPLFHCSIDT VDISVEMCGI 

       550        560        570        580        590        600 
KFPNPFGLAS APPTTSAAMI RRAFEQGWGF ALTKTFGLDK DLVTNVSPRI VRGTTSGHIF 

       610        620        630        640        650        660 
GPGQGSFLNI ELISEKTAAY WCKSVAELKA DFPKNIIIAS IMCSYNQADW TELAKMAQES 

       670        680        690        700        710        720 
QADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRK ATSIPFFAKL TPNVTNIVDI 

       730        740        750        760        770        780 
ATAAYEGGAD GVTATNTVSG LMALKADATP WPGIGRGART TYGGVSGNAI RPIALRAVSA 

       790        800        810        820        830        840 
IARALPGFPI LATGGIDSAE SGLQFLHAGA SVLQVCSAVQ NQDFTVIEDY CLGLKALLYL 

       850        860        870        880        890        900 
KSIEELHDWD GQSPPTIRHQ KGKPVPHVSE LIGKSLPSFG PYLQTKTQAL AKYKKDASGD 

       910        920        930        940        950        960 
VIMDTGAARV NIPKKPIPNV KDVIARALKH IGAYQELDNT EQVQALVDPE MCINCGKCYM 

       970        980        990       1000       1010       1020 
TCNDSGYQAI KFDPETHLPV ITDSCTGCTL CLSVCPIIDC IKMVSRTTPY EPKRGLPVNP 


VC
Q6NYG8 in FASTA format

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