[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Eye; NIH - Zebrafish Gene Collection (ZGC) project; Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-cysteine + O₂ = 3-sulfinoalanine.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2 .
PTM: The thioether cross-link between Cys-93 and Tyr-158 plays a structural role through stabilizing the ferrous ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen (By similarity).
SIMILARITY: Belongs to the cysteine dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC059531; AAH59531.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067344; AAH67344.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_957035.1; -.

UniGene

Dr.79566

3D structure databases

ModBase

Q6NWZ9.

Organism-specific databases

ZFIN

ZDB-GENE-040426-1704; cdo1.

Family and domain databases

InterPro

IPR010300; Cys_dOase_I.
Graphical view of domain structure.

Pfam

PF05995; CDO_I; 1.
Pfam graphical view of domain structure.

BLOCKS

Q6NWZ9.

Genome annotation databases

Ensembl

ENSDARG00000043036; Danio rerio. [Contig view]

GeneID

393714; -.

KEGG

dre:393714; -.

Phylogenomic databases

HOGENOM

Q6NWZ9; -.

HOVERGEN

Q6NWZ9; -.

Other

ProtoNet

Q6NWZ9.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Dioxygenase; Iron; Metal-binding; Oxidoreductase; Thioether bond.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 201`	`201`	`Cysteine dioxygenase type 1.`	`PRO_0000206610`
`METAL`	`86 86`		`Iron; catalytic (By similarity).`
`METAL`	`88 88`		`Iron; catalytic (By similarity).`
`METAL`	`141 141`		`Iron; catalytic (By similarity).`
`CROSSLNK`	`93 158`		`3'-(S-cysteinyl)-tyrosine (Cys-Tyr) (By similarity).`

Sequence information

Length: 201 AA [This is the length of the unprocessed precursor]

Molecular weight: 23474 Da [This is the MW of the unprocessed precursor]

CRC64: 443CF9938F2752A7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEQTEVMKPE TLEDLIKTLH QIFQSDSINV EEVQNLMESY QSNPQDWMKF AKFDQYRYTR 

        70         80         90        100        110        120 
NLVDEGNGKF NLMILCWGEG HGSSIHDHTD SHCFLKLLQG QLKETLFDWP DRKLQSGMKP 

       130        140        150        160        170        180 
RGQSVLQENQ CAYINDSLGL HRVENVSHTE PAVSLHLYSP PFQSCRTFDQ RTGHHNTVKM 

       190        200 
TFWSKYGERT PYELSVSQEN N

Q6NWZ9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools