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UniProtKB/Swiss-Prot entry Q6LWL2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HDRA_METMP
Primary accession number Q6LWL2
Secondary accession numbers None
Integrated into Swiss-Prot on February 26, 2008
Sequence was last modified on February 26, 2008 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 41)
Name and origin of the protein
Protein name CoB--CoM heterodisulfide reductase iron-sulfur subunit A
Synonym EC 1.8.98.1
Gene name
Name: hdrA
OrderedLocusNames: MMP1697
From
Methanococcus maripaludis [TaxID: 39152] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanococcaceae; Methanococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=S2 / LL;
DOI=10.1128/JB.186.20.6956-6969.2004; PubMed=15466049 [NCBI, ExPASy, EBI, Israel, Japan]
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.;
"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis.";
J. Bacteriol. 186:6956-6969(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX950229; CAF31253.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_988817.1; -.
3D structure databases
HSSP Q45560; 1BD6. [HSSP ENTRY / PDB]
ModBase Q6LWL2.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR006076; FAD-dep_OxRdtase.
IPR016040; NAD(P)-bd.
IPR001327; Pyr_OxRdtase_NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01266; DAO; 1.
PF00037; Fer4; 4.
PF00070; Pyr_redox; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PROSITE PS00198; 4FE4S_FER_1; 3.
PS51379; 4FE4S_FER_2; 4.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q6LWL2.
Genome annotation databases
GeneID 2762636; -.
GenomeReviews BX950229_GR; MMP1697.
KEGG mmp:MMP1697; -.
Phylogenomic databases
HOGENOM Q6LWL2; -.
Genome annotation databases
CMR Q6LWL2; MMP1697.
Other
ProtoNet Q6LWL2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Oxidoreductase; Repeat; Selenium; Selenocysteine.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   658  658     CoB--CoM heterodisulfide reductase iron-sulfur subunit A. PRO_0000318646
DOMAIN   236   267  32     4Fe-4S ferredoxin-type 1. 
DOMAIN   284   313  30     4Fe-4S ferredoxin-type 2. 
DOMAIN   575   604  30     4Fe-4S ferredoxin-type 3. 
DOMAIN   607   637  31     4Fe-4S ferredoxin-type 4. 
NP_BIND   150   173  24     FAD (Potential). 
METAL   246   246        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   249   249        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   252   252        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   256   256        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   293   293        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   296   296        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   299   299        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   303   303        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   584   584        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   587   587        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   590   590        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   594   594        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   617   617        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   620   620        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   623   623        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   627   627        Iron-sulfur 3 (4Fe-4S) (Potential). 
NON_STD   197   197        Selenocysteine (Probable). 
Sequence information
Length: 658 AA [This is the length of the unprocessed precursor] Molecular weight: 71281 Da [This is the MW of the unprocessed precursor] CRC64: 0218716DA82E3866 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSDPKVGVFV CYCGANINGA VDCEAVKDFA SELDGVAVAA TYPFMCADPG QGLIKDAIKE 

        70         80         90        100        110        120 
HGLDRIVVAA CTPKIHEPTF RGCLQDAGIS PYYLEFVNIR EHDAFVHMGD VEGATRKACE 

       130        140        150        160        170        180 
MIAGGVERAK KLEDVPQKVV DVDKSCMVIG AGIAGIQSAL DLGDQGFKVY LVDKDESIGG 

       190        200        210        220        230        240 
RMAQLAKTFP TDDCAMUILA PKMVSAANHP NIELITFAEI KNIDGYIGNF DVTLEKKPRY 

       250        260        270        280        290        300 
VDEDTCTGCG ACAAACPIEV PNEFDLGLGT RKAIYVPFPQ AVPLLYTIDK EHCIDCGLCA 

       310        320        330        340        350        360 
KVCCAEAVRY DQKPQELNIK VGTIITATGY DEFDATKKEE YGYGVYDNVI TTLEVERMIN 

       370        380        390        400        410        420 
PAGPTHGHEI RPSDGKAPKR TVYIQCVGSR DEKVGNPYCS RVCCMFALKN AQLMKMHDPN 

       430        440        450        460        470        480 
AEVYICYMDI RAFGKGYEEY YKRAQDQFGV KFIRGRPANI FEDPETKNLT VRVEDTLMGE 

       490        500        510        520        530        540 
ILEIDADLVV LSAGLEAKKD AGELAKMLGI DRGPEGFFKE LHPKLAPVNT KVDGIAIAGV 

       550        560        570        580        590        600 
AQGPKDIPDT VAQAKGAASA VAIPMSQGQF KIEMIRATVN EEVCGGCKVC ALMCPYNAIT 

       610        620        630        640        650 
YEEKDGHLVA ITDDVACKGC GACAAACPSG AMQLRYYRDE QVIGMIDGIL NAAKMLEE
Q6LWL2 in FASTA format

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