ID   ASTD_PHOPR              Reviewed;         485 AA.
AC   Q6LVE5;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-NOV-2008, entry version 33.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=PBPRA0291;
OS   Photobacterium profundum (Photobacterium sp. (strain SS9)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Photobacterium.
OX   NCBI_TaxID=74109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15746425; DOI=10.1126/science.1103341;
RA   Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N.,
RA   Lauro F.M., Cestaro A., Malacrida G., Simionati B., Cannata N.,
RA   Romualdi C., Bartlett D.H., Valle G.;
RT   "Life at depth: Photobacterium profundum genome sequence and
RT   expression analysis.";
RL   Science 307:1459-1461(2005).
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CR378663; CAG18730.1; -; Genomic_DNA.
DR   RefSeq; YP_128532.1; -.
DR   GeneID; 3123901; -.
DR   GenomeReviews; CR354531_GR; PBPRA0291.
DR   KEGG; ppr:PBPRA0291; -.
DR   NMPDR; fig|298386.1.peg.2516; -.
DR   HOGENOM; Q6LVE5; -.
DR   BioCyc; PPRO298386:PBPRA0291-MON; -.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:InterPro.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    485       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000262409.
FT   NP_BIND     220    225       NAD (By similarity).
FT   ACT_SITE    243    243       By similarity.
FT   ACT_SITE    278    278       By similarity.
SQ   SEQUENCE   485 AA;  51848 MW;  0CF9CA7994567463 CRC64;
     MTQWIAGNWL AGKGEAMNSL NPFSSEEIWQ GDAATAEQVE QAVSAAREAL TTWRKTDLSE
     RQAVVEKFAE LVKEHSEHIA HTIAEETGKP LWETRTEAGA MVGKIAISLR AYHERTGEKQ
     KDIAGTAAVL RHRPLGVMAV FGPYNFPGHL PNGHIVPALL SGNTVVFKPS ELTPKVAQET
     MKLWEQAGLP KGVLNMVQGA RPTGEALAGS KGIDGLLFTG SANTGHILHR QYAGQPGKML
     ALEMGGNNPM VISKSYGELD ATVYTIIQSA FISAGQRCTC ARRLYLPQGI EGDAILNRLV
     EATAKIRIGG PFAEPQPFMG PQISERAADG IIAAQANLVS LGGEVLLEAI RGQGAIVSPA
     IIEVSNVAEL PDEEYFGPLL QVVRYQDLPD AVELANDTRY GLSAGLVSTD DSEWQYFIDN
     IRAGIVNRNR QLTGASGDAP FGGPGASGNL RPSAYYAADY CAYPMASMEG EQTELPAQLS
     PGIAL
//