NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828;
DOI=10.1073/pnas.0401356101; PubMed=15184674 [NCBI, ExPASy, EBI, Israel, Japan]
Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C., Schepers B., Dock C., Antranikian G., Liebl W.;
"Genome sequence of Picrophilus torridus and its implications for life around pH 0.";
Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004).

Comments

FUNCTION: This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA (By similarity).
CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
SIMILARITY: Belongs to the ATP-dependent DNA ligase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE017261; AAT43257.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_023450.1; -.

3D structure databases

ModBase

Q6L195.

Enzyme and pathway databases

BioCyc

PTOR263820:PTO0672-MON; -.

Ontologies

GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from InterPro).
GO:0003910;	Molecular function: DNA ligase (ATP) activity (inferred from electronic annotation from HAMAP).
GO:0007049;	Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0051301;	Biological process: cell division (inferred from electronic annotation from UniProtKB-KW).
GO:0006310;	Biological process: DNA recombination (inferred from electronic annotation from HAMAP).
GO:0006281;	Biological process: DNA repair (inferred from electronic annotation from HAMAP).
GO:0006260;	Biological process: DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00407; -; 1.
PBIL [Tree]

InterPro

IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR012308; DNA_ligase_A_N.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.50.140; OB_NA_bd_sub; 1.

Pfam

PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
PF04675; DNA_ligase_A_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00574; dnl1; 1.

PROSITE

PS00697; DNA_LIGASE_A1; FALSE_NEG.
PS00333; DNA_LIGASE_A2; FALSE_NEG.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q6L195.

Genome annotation databases

GeneID

2845337; -.

GenomeReviews

AE017261_GR; PTO0672.

KEGG

pto:PTO0672; -.

NMPDR

fig|263820.1.peg.672; -.

Phylogenomic databases

HOGENOM

Q6L195; -.

Genome annotation databases

CMR

Q6L195; PTO0672.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 590`	`590`	`DNA ligase.`	`PRO_0000059610`
`ACT_SITE`	`255 255`		`N6-AMP-lysine intermediate (By similarity).`

Sequence information

Length: 590 AA [This is the length of the unprocessed precursor]

Molecular weight: 66969 Da [This is the MW of the unprocessed precursor]

CRC64: 5DF71B6B15B51439 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLYINMDFSD VASYFSRMEE TTKRLELTSI LAELFKRSGD DLKKLVYLVQ GKLMPDYLGI 

        70         80         90        100        110        120 
ELGLSDKLII KSLSKASGRS EEDINRIFSR LGDLGSTAEE ISSSGIQRPL LKESLTVDYV 

       130        140        150        160        170        180 
YNQLIKISGY TGHGSIKTKM DAYIDLLINS GPMEIKYITR IITGKLRLGV ADSTILDGLI 

       190        200        210        220        230        240 
EAFSEKKYAD DIETAYNFHP DLGYIAENLM MGNINELLNA GPVPLIPFKV MLAERLQSIS 

       250        260        270        280        290        300 
DIRNKMGHNA SYEYKYDGLR TQLHFLKGGI KIFSRGLEET TSSFPDIVQN FKSYYSFDSC 

       310        320        330        340        350        360 
IIDGESVPYN PETGELYPFQ MVSKRRGRKY ELTEKTREVP IVMFIFDILY LNGKSLVNLP 

       370        380        390        400        410        420 
YPERRSILEK NFKENEYFKL AKRIVSDDEH DIMKFFERSI EEGCEGIVAK SNGIDSIYRA 

       430        440        450        460        470        480 
GARGWLWIKF KRDYQSELSD SLDLVVVGAF DGHGRRKGTF GALLLACYNS KDDTFETVCK 

       490        500        510        520        530        540 
LGSGFTDEML SEMPRLLGDK IVEKKPARVN SSMEPDHWIY PSLVLEIRGA EITVSPVHTC 

       550        560        570        580        590 
AMNIIEKGSG LALRFPRLIK PRDDKKPEDA TTTNEIIEMY KAQKKVIEKS

Q6L195 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools