ID   ILVC1_BACHK             Reviewed;         336 AA.
AC   Q6HLF4;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   04-NOV-2008, entry version 29.
DE   RecName: Full=Ketol-acid reductoisomerase 1;
DE            EC=1.1.1.86;
DE   AltName: Full=Acetohydroxy-acid isomeroreductase 1;
DE   AltName: Full=Alpha-keto-beta-hydroxylacil reductoisomerase 1;
GN   Name=ilvC1; OrderedLocusNames=BT9727_1283;
OS   Bacillus thuringiensis subsp. konkukian.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=180856;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=97-27;
RX   PubMed=16621833; DOI=10.1128/JB.188.9.3382-3390.2006;
RA   Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S.,
RA   Bruce D., Campbell C.S., Campbell M.L., Chen J., Chertkov O.,
RA   Cleland C., Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T.,
RA   Goodwin L.A., Hill K.K., Hitchcock P., Jackson P.J., Keim P.,
RA   Kewalramani A.R., Longmire J., Lucas S., Malfatti S., McMurry K.,
RA   Meincke L.J., Misra M., Moseman B.L., Mundt M., Munk A.C.,
RA   Okinaka R.T., Parson-Quintana B., Reilly L.P., Richardson P.,
RA   Robinson D.L., Rubin E., Saunders E., Tapia R., Tesmer J.G.,
RA   Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L.,
RA   Brettin T.S., Gilna P.;
RT   "Pathogenomic sequence analysis of Bacillus cereus and Bacillus
RT   thuringiensis isolates closely related to Bacillus anthracis.";
RL   J. Bacteriol. 188:3382-3390(2006).
CC   -!- CATALYTIC ACTIVITY: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)
CC       = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
CC   -!- CATALYTIC ACTIVITY: (2R,3R)-2,3-dihydroxy-3-methylpentanoate +
CC       NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 2/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 2/4.
CC   -!- SIMILARITY: Belongs to the ketol-acid reductoisomerase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE017355; AAT62183.1; -; Genomic_DNA.
DR   RefSeq; YP_035617.1; -.
DR   GeneID; 2858689; -.
DR   GenomeReviews; AE017355_GR; BT9727_1283.
DR   KEGG; btk:BT9727_1283; -.
DR   NMPDR; fig|281309.1.peg.1257; -.
DR   HOGENOM; Q6HLF4; -.
DR   BioCyc; BTHU281309:BT9727_1283-MON; -.
DR   GO; GO:0004455; F:ketol-acid reductoisomerase activity; IEA:HAMAP.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00435; -; 1.
DR   InterPro; IPR013023; AcH_isomrdctse.
DR   InterPro; IPR000506; AcH_isomrdctse_C.
DR   InterPro; IPR013116; IlvN.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR21371; AcH_isomrdctse; 1.
DR   Pfam; PF01450; IlvC; 1.
DR   Pfam; PF07991; IlvN; 1.
DR   TIGRFAMs; TIGR00465; ilvC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    336       Ketol-acid reductoisomerase 1.
FT                                /FTId=PRO_0000226159.
FT   ACT_SITE    107    107       Potential.
SQ   SEQUENCE   336 AA;  36779 MW;  4049B6C0159A71D5 CRC64;
     MAKVYYEKDV TVNVLKEKKV AIIGYGSQGH AHAQNLRDNG FDVVVGLRKG KSWDKAKEDG
     FSVYTVAEAA KKADVVMILL PDELQPEVYE AEIAPNLQAG NSLVFAHGFN VHFDQVKPPV
     NVDVFLVAPK GPGHLVRRTF VEGGAVPALF AVYQDATGVA TEKALSYADG IGATRAGVLE
     TTFKEETETD LFGEQAVLCG GVTALVKAGF ETLVDAGYQP ELAYFECLHE LKLIVDLMYE
     GGLENMRYSV SDTAQWGDFV SGPRVVTEDT KKAMDTVLAE IQDGTFARGW IAEHKAGRPN
     FHATNEKENE HEIEVVGRKL REMMPFVQPR VKAGVK
//