FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ (By similarity).
CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O₂ = 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O.
PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis .
SIMILARITY: Belongs to the pqqC family.

Copyright

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Cross-references

Sequence databases

EMBL

CR543861; CAG69273.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_047095.1; -.

3D structure databases

SMR

Q6F9J1; 5-254.

ModBase

Q6F9J1.

Enzyme and pathway databases

BioCyc

ASP62977:ACIAD2505-MON; -.

Ontologies

GO:0033732;	Molecular function: pyrroloquinoline-quinone synthase activity (inferred from electronic annotation from EC).
GO:0018189;	Biological process: pyrroloquinoline quinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00654; -; 1.
PBIL [Tree]

InterPro

IPR016084; Haem_Oase-like_multi-hlx.
IPR011845; PQQ_synth_PqqC.
IPR004305; TENA/THI4/PQQ_synth_PqqC.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.910.10; Haem_Oase-like_multi-hlx; 1.

Pfam

PF03070; TENA_THI-4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02111; PQQ_syn_pqqC; 1.

BLOCKS

Q6F9J1.

Genome annotation databases

GeneID

2879637; -.

GenomeReviews

CR543861_GR; ACIAD2505.

KEGG

aci:ACIAD2505; -.

NMPDR

fig|62977.3.peg.2104; -.

Phylogenomic databases

HOGENOM

Q6F9J1; -.

Genome annotation databases

CMR

Q6F9J1; ACIAD2505.

Other

ProtoNet

Q6F9J1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase; PQQ biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 255`	`255`		`Pyrroloquinoline-quinone synthase.`	`PRO_0000219975`

Sequence information

Length: 255 AA [This is the length of the unprocessed precursor]

Molecular weight: 29662 Da [This is the MW of the unprocessed precursor]

CRC64: B7EA183D0DF7A76A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRFNMTTTLF SPAEFEQALR DKGRYYHIHH PYHIMMNDGH ATKQQIQGWV ANRFYYQVNI 

        70         80         90        100        110        120 
PLKDAAIMAN CPDPATRRKW VQRILDHDGQ HDDHGGIEAW LRLGEAVGLD RETILSQKMV 

       130        140        150        160        170        180 
LPSVRFAVDA YVNFARRACW QEAACSSLTE LFAPAIHQSR LDTWPTHYPW IDAEGYAYFR 

       190        200        210        220        230        240 
GRLSQANRDV EHGLELALEY CNTVDRQQRM LNILQFKLDI LWTILDGMSM AYVLERAPYH 

       250 
TVTQEAVWHQ KGLLG

Q6F9J1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools