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[1]
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NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY, AND INDUCTION.
TISSUE=Heart;
DOI=10.1016/j.abb.2004.11.020; PubMed=15680912 [NCBI, ExPASy, EBI, Israel, Japan]
Eddy S.F.,
McNally J.D.,
Storey K.B.;
"Up-regulation of a thioredoxin peroxidase-like protein, proliferation-associated gene, in hibernating bats.";
Arch. Biochem. Biophys. 435:103-111(2005).
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- FUNCTION: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity).
- CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
- SUBUNIT: Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2 (By similarity).
- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Melanosome (By similarity).
- TISSUE SPECIFICITY: Detected in heart and skeletal muscle (at protein level).
- INDUCTION: Up-regulated in hearts from hiberbating bats.
- MISCELLANEOUS: The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin (By similarity).
- MISCELLANEOUS: Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized (By similarity).
- SIMILARITY: Belongs to the ahpC/TSA family.
- SIMILARITY: Contains 1 thioredoxin domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 199 AA [This is the length of the unprocessed precursor] |
Molecular weight: 22124 Da [This is the MW of the unprocessed precursor] |
CRC64: A75F3D21C40322CD [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS
70 80 90 100 110 120
DRAEEFKKIN CQVIGASVDS HFCHLAWINT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK
130 140 150 160 170 180
ADEGISFRGL FIIDDKGILR QITVNDLPVG RSVDETLRLV QAFQFTDKHG EVCPAGWKPG
190
SDTIKPDVQK SKEYFSKQK
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Q6B4U9 in FASTA format |
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