[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Testis; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

CATALYTIC ACTIVITY: N⁶-(L-1,3-dicarboxypropyl)-L-lysine + NAD⁺ + H₂O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADH.
PATHWAY: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6 .
SIMILARITY: Belongs to the saccharopine dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC079215; AAH79215.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001014007.1; -.

UniGene

Rn.23989

3D structure databases

ModBase

Q6AY30.

Organism-specific databases

RGD

1311440; Sccpdh.

Gene expression databases

ArrayExpress

Q6AY30; -.

GermOnline

ENSRNOG00000037984; Rattus norvegicus.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR005097; Saccharopine_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF03435; Saccharop_dh; 1.
Pfam graphical view of domain structure.

BLOCKS

Q6AY30.

Genome annotation databases

Ensembl

ENSRNOG00000037984; Rattus norvegicus. [Contig view]

GeneID

305021; -.

KEGG

rno:305021; -.

NMPDR

fig|10116.3.peg.9663; -.

Phylogenomic databases

HOVERGEN

Q6AY30; -.

Other

ProtoNet

Q6AY30.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 429`	`429`		`Probable saccharopine dehydrogenase.`	`PRO_0000212843`

Sequence information

Length: 429 AA [This is the length of the unprocessed precursor]

Molecular weight: 47088 Da [This is the MW of the unprocessed precursor]

CRC64: D16F3BE0BBF8D300 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MATEQRPFQL VVFGASGFTG QFVTEEVARE QMASEQSSRL PWAVAGRSKE KLQQVLEKAA 

        70         80         90        100        110        120 
QKLGRATLSS EVGIIICDIS NPASLDEMAK KATLVLNCVG PYRFYGEPVV KACIENGTSC 

       130        140        150        160        170        180 
IDICGEPQFL ELMHVKYHEK AAEKGVYIIG SSGFDSIPAD LGVLYTRNQM NGTLTAVESF 

       190        200        210        220        230        240 
LTINSGPEGL CIHDGTWKSA IYGFGDKGSL RKLRSVSNLK PVPVIGSKLK RRWPVSYCRE 

       250        260        270        280        290        300 
LNSYAIPFLG SDMSVVKRTQ RYLHENLEDS PVQYAAYITV GGITSVIKLM FAGLFFLFFV 

       310        320        330        340        350        360 
KFSIGRQLLV KFPWLFSFGY FSKRGPTQKQ MDESSFTMTF FGQGYSHGVS AEKNKPNIRI 

       370        380        390        400        410        420 
CTQVKGPEAG YVATPIAMVQ AAVTFLNDAS DLPKGGGVFT PGAAFSRTKL IDRLNQHGIQ 


FSVISSSEV

Q6AY30 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools