[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Testis; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC079222; AAH79222.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001012208.1; -.

UniGene

Rn.137266

3D structure databases

SMR

Q6AY23; 1-275.

ModBase

Q6AY23.

Organism-specific databases

RGD

1310074; Pycr2.

Gene expression databases

ArrayExpress

Q6AY23; -.

GermOnline

ENSRNOG00000003267; Rattus norvegicus.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGR00112; proC; 1.

PS00521; P5CR; 1.

Genome annotation databases

Ensembl

ENSRNOG00000003267; Rattus norvegicus. [Contig view]

GeneID

364064; -.

KEGG

rno:364064; -.

NMPDR

fig|10116.3.peg.9681; -.

Phylogenomic databases

HOVERGEN

Q6AY23; -.

Other

ProtoNet

Q6AY23.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 320`	`320`		`Pyrroline-5-carboxylate reductase 2.`	`PRO_0000187320`

Sequence information

Length: 320 AA [This is the length of the unprocessed precursor]

Molecular weight: 33673 Da [This is the MW of the unprocessed precursor]

CRC64: 6434E5A7CBC739A9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSVGFIGAGQ LACALARGFT AAGVLSAHKI IASSPEMDLP TVSALRKMGV NLTRSNKDTV 

        70         80         90        100        110        120 
RHSDVLFLAV KPHIIPFILD EIGADVQERH IVVSCAAGVT ISSVEKKLMA FQPAPKVIRC 

       130        140        150        160        170        180 
MTNTPVVVRE GATVYATGTH ALVEDGKLLE QLMSSVGFCT EVEEDLIDAI TGLSGSGPAY 

       190        200        210        220        230        240 
AFMALDALAD GGVKMGVPRR LAVRLGAQAL LGAAKMLLDS EDHPGQLKDN VCSPGGATIH 

       250        260        270        280        290        300 
ALHFLESGGF RSLLINAVEA SCIRTRELQS MADQEKVSPA ALKKTLLDRV KLESPTVSTL 

       310        320 
APPSSGKLLT RNPAQGSKRE

Q6AY23 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools