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UniProtKB/Swiss-Prot entry Q69BJ6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UCRI_HYLSY
Primary accession number Q69BJ6
Secondary accession numbers None
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on September 13, 2004 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 30)
Name and origin of the protein
Protein name Cytochrome b-c1 complex subunit Rieske, mitochondrial [Precursor]
Synonyms EC 1.10.2.2
Ubiquinol-cytochrome c reductase iron-sulfur subunit
Rieske iron-sulfur protein
RISP
Complex III subunit 5
Contains Cytochrome b-c1 complex subunit 11
     (Ubiquinol-cytochrome c reductase 8 kDa protein)
     (Complex III subunit IX)
Gene name
Name: UQCRFS1
From
Hylobates syndactylus (Siamang) (Symphalangus syndactylus) [TaxID: 9590] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Symphalangus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Doan J.W., Wildman D.E., Schmidt T.R., Weiss M.L., Goodman M., Grossman L.I.;
"Molecular evolution of the iron sulfur protein and subunit 9 of complex III of the electron transport chain in primates.";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Comments
  • FUNCTION: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity).
  • FUNCTION: The transit peptide of the Rieske protein seems to form part of the bc1 complex and is considered to be the subunit 11/IX of that complex (By similarity).
  • CATALYTIC ACTIVITY: QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H+.
  • COFACTOR: Binds 1 2Fe-2S cluster per subunit (By similarity).
  • SUBUNIT: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) (By similarity).
  • SUBCELLULAR LOCATION: Mitochondrion inner membrane (By similarity).
  • MISCELLANEOUS: The Rieske protein is a high potential 2Fe-2S protein.
  • SIMILARITY: Contains 1 Rieske domain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY387516; AAR32729.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY387515; AAR32729.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
SMR Q69BJ6; 1-57, 79-274.
ModBase Q69BJ6.
Family and domain databases
InterPro IPR014349; Rieske.
IPR005805; Rieske_C.
IPR006317; Rieske_proteo.
IPR005806; Rieske_reg.
IPR015248; Ubiq_cytc_red_N.
IPR004192; UCR_TM_region.
Graphical view of domain structure.
Gene3D G3DSA:2.102.10.10; Rieske_reg; 1.
PANTHER PTHR10134; Rieske; 1.
Pfam PF00355; Rieske; 1.
PF09165; Ubiq-Cytc-red_N; 1.
PF02921; UCR_TM; 1.
Pfam graphical view of domain structure.
PRINTS PR00162; RIESKE.
TIGRFAMs TIGR01416; Rieske_proteo; 1.
PROSITE PS51296; RIESKE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q69BJ6.
Phylogenomic databases
HOVERGEN Q69BJ6; -.
Other
ProtoNet Q69BJ6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
2Fe-2S; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Respiratory chain; Transit peptide; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1    78  78     Cytochrome b-c1 complex subunit 11 (By similarity). PRO_0000307242
TRANSIT   1    78  78     Mitochondrion (By similarity). 
CHAIN   79   274  196     Cytochrome b-c1 complex subunit Rieske (By similarity). PRO_0000030665
DOMAIN   187   272  86     Rieske. 
METAL   217   217        Iron-sulfur (2Fe-2S) (By similarity). 
METAL   219   219        Iron-sulfur (2Fe-2S); via pros nitrogen (By similarity). 
METAL   236   236        Iron-sulfur (2Fe-2S) (By similarity). 
METAL   239   239        Iron-sulfur (2Fe-2S); via pros nitrogen (By similarity). 
DISULFID   222   238        By similarity. 
Sequence information
Length: 274 AA [This is the length of the unprocessed precursor] Molecular weight: 29664 Da [This is the MW of the unprocessed precursor] CRC64: 005615CAEE94C725 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLSVAARSGP FAPVLSATSR GVAGALRPLV QATVPATPEQ PVLDLKRPFL SRESLSGQAV 

        70         80         90        100        110        120 
RRPLVASVGL NVPASVCYSH TDVKVPDFSE YRRPEVLDST KSSRESSEAR KGFSYLVTAV 

       130        140        150        160        170        180 
TTVGVAYAAK NAVTQFVSSM SASADVLALA KIEIKLSDIP EGKNMAFKWR GKPLFVRHRT 

       190        200        210        220        230        240 
QKEIEQEAAV ELSQLRDPQH DLDRVKRPEW VILIGVCTHL GCVPIANAGD FGGYYCPCHG 

       250        260        270 
SHYDASGRIR LGPAPLNLEV PTYEFTSDDM VIVG 

Q69BJ6 in FASTA format

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