ID   ASPD_DANRE              Reviewed;         276 AA.
AC   Q66I59;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-NOV-2008, entry version 36.
DE   RecName: Full=Putative L-aspartate dehydrogenase;
DE            EC=1.4.1.21;
GN   ORFNames=zgc:103722;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Specifically catalyzes the NAD or NADP-dependent
CC       dehydrogenation of L-aspartate to iminoaspartate (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate
CC       + NH(3) + NAD(P)H.
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis;
CC       iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.
CC   -!- MISCELLANEOUS: The iminoaspartate product is unstable in aqueous
CC       solution and can decompose to oxaloacetate and ammonia (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the L-aspartate dehydrogenase family.
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DR   EMBL; BC081519; AAH81519.1; -; mRNA.
DR   RefSeq; NP_001004657.1; -.
DR   UniGene; Dr.87480; -.
DR   Ensembl; ENSDARG00000038297; Danio rerio.
DR   GeneID; 447919; -.
DR   KEGG; dre:447919; -.
DR   ZFIN; ZDB-GENE-040912-102; zgc:103722.
DR   HOGENOM; Q66I59; -.
DR   HOVERGEN; Q66I59; -.
DR   GO; GO:0033735; F:aspartate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR   GO; GO:0006742; P:NADP catabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR005106; Asp/hSer_DHase_NAD-bd.
DR   InterPro; IPR002811; Asp_DHase.
DR   InterPro; IPR011182; Asp_DHase_NAD_syn.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01958; DUF108; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF005227; Asp_dh_NAD_syn; 1.
DR   ProDom; PD017325; Asp_dh; 1.
PE   2: Evidence at transcript level;
KW   NAD; NADP; Oxidoreductase; Pyridine nucleotide biosynthesis.
FT   CHAIN         1    276       Putative L-aspartate dehydrogenase.
FT                                /FTId=PRO_0000144903.
FT   BINDING     126    126       NAD; via amide nitrogen (By similarity).
FT   BINDING     192    192       NAD (By similarity).
SQ   SEQUENCE   276 AA;  29753 MW;  8DEC2D2AEB852CA9 CRC64;
     MADKALKVGI VGYGHLGQFL VEKIQSEGAE VGLQLAFVWN RNADKLKDSL PKDLILHDLS
     DFTQRDTDVI VEVCHPLIVK EFGVRFLSHA HFLVGSPSAL SDGQLEQDLR TAAKQQGKTL
     YVPSGALWGG QDIQKMNDSG TLRALSIRMS KHPSCFRLTG GLLSDWTEGE GRRVLYRGSV
     AELCPLAPNN VNTMAAAAIA ASKLGFHGVT GEIVSDTALA DYHVVEVDVT GPDGFSVKTM
     RQNPAKLGAV TGKATYNSFW SSLLVCKGHG GRVYLC
//