[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Liver; NIH - Zebrafish Gene Collection (ZGC) project; Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity).
CATALYTIC ACTIVITY: L-aspartate + H₂O + NAD(P)⁺ = oxaloacetate + NH₃ + NAD(P)H.
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1 .
MISCELLANEOUS: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia (By similarity).
SIMILARITY: Belongs to the L-aspartate dehydrogenase family.

Copyright

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Cross-references

Sequence databases

EMBL

BC081519; AAH81519.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001004657.1; -.

UniGene

Dr.87480

3D structure databases

ModBase

Q66I59.

Organism-specific databases

ZFIN

ZDB-GENE-040912-102; zgc:103722.

Family and domain databases

InterPro

IPR005106; Asp/hSer_DHase_NAD-bd.
IPR002811; Asp_DHase.
IPR011182; Asp_DHase_NAD_syn.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01958; DUF108; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF005227; Asp_dh_NAD_syn; 1.

ProDom

PD017325; Asp_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]

BLOCKS

Q66I59.

Genome annotation databases

Ensembl

ENSDARG00000038297; Danio rerio. [Contig view]

GeneID

447919; -.

KEGG

dre:447919; -.

Phylogenomic databases

HOGENOM

Q66I59; -.

HOVERGEN

Q66I59; -.

Other

ProtoNet

Q66I59.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; NADP; Oxidoreductase; Pyridine nucleotide biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 276`	`276`	`Putative L-aspartate dehydrogenase.`	`PRO_0000144903`
`BINDING`	`126 126`		`NAD; via amide nitrogen (By similarity).`
`BINDING`	`192 192`		`NAD (By similarity).`

Sequence information

Length: 276 AA [This is the length of the unprocessed precursor]

Molecular weight: 29753 Da [This is the MW of the unprocessed precursor]

CRC64: 8DEC2D2AEB852CA9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MADKALKVGI VGYGHLGQFL VEKIQSEGAE VGLQLAFVWN RNADKLKDSL PKDLILHDLS 

        70         80         90        100        110        120 
DFTQRDTDVI VEVCHPLIVK EFGVRFLSHA HFLVGSPSAL SDGQLEQDLR TAAKQQGKTL 

       130        140        150        160        170        180 
YVPSGALWGG QDIQKMNDSG TLRALSIRMS KHPSCFRLTG GLLSDWTEGE GRRVLYRGSV 

       190        200        210        220        230        240 
AELCPLAPNN VNTMAAAAIA ASKLGFHGVT GEIVSDTALA DYHVVEVDVT GPDGFSVKTM 

       250        260        270 
RQNPAKLGAV TGKATYNSFW SSLLVCKGHG GRVYLC

Q66I59 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools