[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Kidney; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T helper type 2-associated cytokines (By similarity).
SUBCELLULAR LOCATION: Secreted (By similarity).
PTM: Proteolytically converted to a mature form by CASP1 (By similarity).
SIMILARITY: Belongs to the IL-1 family. Highly divergent.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC081993; AAH81993.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00471802; -.

NP_001014188.1; -.

3D structure databases

ModBase

Q66H70.

Organism-specific databases

RGD

1311155; Il33.

Gene expression databases

ArrayExpress

Q66H70; -.

GermOnline

ENSRNOG00000016456; Rattus norvegicus.

Ontologies

GO:0005615;	Cellular component: extracellular space (inferred from electronic annotation from UniProtKB-KW).
GO:0005125;	Molecular function: cytokine activity (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Genome annotation databases

Ensembl

ENSRNOG00000016456; Rattus norvegicus. [Contig view]

GeneID

361749; -.

KEGG

rno:361749; -.

Phylogenomic databases

HOVERGEN

Q66H70; -.

Other

677492; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytokine; Secreted.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`PROPEP`	`1 ?`		`Potential.`	`PRO_0000248848`
`CHAIN`	`? 264`		`Interleukin-33.`	`PRO_0000096793`

Sequence information

Length: 264 AA [This is the length of the unprocessed precursor]

Molecular weight: 29486 Da [This is the MW of the unprocessed precursor]

CRC64: 91452ADC579B7BCC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRPRMKYSNS KISPAKCDST SGRALVPPCK ITRSQQKTKD ICHVYCMRLR SGLTIRKETC 

        70         80         90        100        110        120 
YFGKEPAKRY SLKSGSKHEG RLSTCLPDSR KRSLLGSIQA FAASVDTLSI QGTSLLTESC 

       130        140        150        160        170        180 
ALSTYNDQSV SFVLENGCYV INVEDCGKNQ EKDKVLLRYY ESSFPAQSGD GVDGKKLMVN 

       190        200        210        220        230        240 
MSPIKDTDIW LNANDKDYSV ELQKGDVSPP DQAFFVLHKK SSDFVSFECK NLPGTYIGVK 

       250        260 
DNQLALVEEN DESCNNIMFK LSKM

Q66H70 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools