NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=YCH46;
DOI=10.1073/pnas.0404172101; PubMed=15466707 [NCBI, ExPASy, EBI, Israel, Japan]
Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.";
Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).

Comments

FUNCTION: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate + NADP⁺ = L-glutamyl 5-phosphate + NADPH.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the gamma-glutamyl phosphate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP006841; BAD47247.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_097781.1; -.

3D structure databases

ModBase

Q64Z29.

Enzyme and pathway databases

BioCyc

BFRA295405:BF0498-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004350;	Molecular function: glutamate-5-semialdehyde dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006561;	Biological process: proline biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00412; -; 1.
PBIL [Tree]

InterPro

IPR016163; Ald_DHase_C.
IPR016162; Ald_DHase_N.
IPR000965; Gglut_pp_reduct.
IPR012134; Glu-5-SA_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11063:SF1; GSA_DH; 1.

PIRSF000151; GPR; 1.

TIGR00407; proA; 1.

PS01223; PROA; 1.

Genome annotation databases

GeneID

3082671; -.

GenomeReviews

AP006841_GR; BF0498.

KEGG

bfr:BF0498; -.

Phylogenomic databases

HOGENOM

Q64Z29; -.

Genome annotation databases

CMR

Q64Z29; BF0498.

Other

ProtoNet

Q64Z29.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 415`	`415`		`Gamma-glutamyl phosphate reductase.`	`PRO_0000189690`

Sequence information

Length: 415 AA [This is the length of the unprocessed precursor]

Molecular weight: 45705 Da [This is the MW of the unprocessed precursor]

CRC64: B3D5059FB4C84A70 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNLNDTFAAV QAAGRHLALL PDDRINQILN AVAEAALEQT SYILSENRKD LERMSPDNPK 

        70         80         90        100        110        120 
YDRLRLTEER LRGIASDIRN VATLPSPLGR ILKESIRPNG MRLTKISVPF GVIGIIYEAR 

       130        140        150        160        170        180 
PNVSFDVFSL CLKSGNACIL KGGSDADYSN RAIVEVIHQV LRQFNIDTHM VELLPADREA 

       190        200        210        220        230        240 
TRELLHATGY VDLIIPRGSS ALINFVRQNA TIPVIETGAG ICHTYFDEYG DTAKGAAIIH 

       250        260        270        280        290        300 
NAKTRRVSVC NALDCVIVHE SRLSDLPLLC EKLKADKVII YADPSAYQAL EGHYPAGLLK 

       310        320        330        340        350        360 
PATPESFGTE FLDYKMAIKT VNSFENALGH IQEYSSRHSE SIVTENPERA ALFTRMVDAA 

       370        380        390        400        410 
CVYTNVSTAF TDGAQFGLGA EIGISTQKLH ARGPMGLEEI TSYKWIIEGD GQTRQ

Q64Z29 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools