[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. DOI=10.1038/ng1431; PubMed=15378063 [NCBI, ExPASy, EBI, Israel, Japan] Burki F., Kaessmann H.; "Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux."; Nat. Genet. 36:1061-1063(2004).

Comments

FUNCTION: Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
CATALYTIC ACTIVITY: L-glutamate + H₂O + NAD(P)⁺ = 2-oxoglutarate + NH₃ + NAD(P)H.
SUBUNIT: Homohexamer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY588268; AAU03134.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q64I00; 58-558.

ModBase

Q64I00.

Ontologies

GO:0005759;	Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11606:SF2; GLFV_DH; 1.

Pfam

PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR00082; GLFDHDRGNASE.

PROSITE

PS00074; GLFV_DEHYDROGENASE; 1.

BLOCKS

Q64I00.

Phylogenomic databases

HOVERGEN

Q64I00; -.

Other

ProtoNet

Q64I00.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Mitochondrion; NADP; Oxidoreductase; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 53`	`53`	`Mitochondrion (By similarity).`
`CHAIN`	`54 558`	`505`	`Glutamate dehydrogenase 2, mitochondrial.`	`PRO_0000007211`
`ACT_SITE`	`183 183`		`By similarity.`
`BINDING`	`84 84`		`Substrate (By similarity).`

Sequence information

Length: 558 AA [This is the length of the unprocessed precursor]

Molecular weight: 61386 Da [This is the MW of the unprocessed precursor]

CRC64: EF26FEC7089E5D44 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MYRYLGKALL LSRAGPAALG SAANHSAALL GRARGQPAAA SQPGLALASR RHYSELVADR 

        70         80         90        100        110        120 
EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN RVRGILRIIK PCNHVLSLSF 

       130        140        150        160        170        180 
PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG 

       190        200        210        220        230        240 
GAKAGVKINP KNYTENELEK ITRRFTMELA KKGFIGPGID VPAPDMNTGE REMSWIADTY 

       250        260        270        280        290        300 
ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SNVGMTPGFG 

       310        320        330        340        350        360 
DKTFVVQGFG NVGLHSMRYL HRFGAKCVAV GESDGSIWNP DGIDPKELED FRLQHGSILG 

       370        380        390        400        410        420 
FPKAKPYEGS ILEADCDILI PAATEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER 

       430        440        450        460        470        480 
NILVIPDVYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK 

       490        500        510        520        530        540 
HGGTIPIVPT AEFRDSISGA SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV 

       550 
NAIEKVFKVY SEAGVTFT

Q64I00 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools