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UniProtKB/Swiss-Prot entry Q64442


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHSO_MOUSE
Primary accession number Q64442
Secondary accession numbers Q569V5 Q9CPS0
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on July 10, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 90)
Name and origin of the protein
Protein name Sorbitol dehydrogenase
Synonyms EC 1.1.1.14
L-iditol 2-dehydrogenase
Gene name
Name: Sord
Synonyms: Sdh1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c;
TISSUE=Liver;
PubMed=7601136 [NCBI, ExPASy, EBI, Israel, Japan]
Lee F.K., Lee A.Y.W., Lin C.X.F., Chung S.S.-M., Chung S.K.;
"Cloning, sequencing, and determination of the sites of expression of mouse sorbitol dehydrogenase cDNA.";
Eur. J. Biochem. 230:1059-1065(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Blastocyst, Lung, and Testis;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
The mouse genome sequencing consortium;
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney, and Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr800223m; PubMed=18630941 [NCBI, ExPASy, EBI, Israel, Japan]
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.";
J. Proteome Res. 7:3957-3967(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U27014; AAA79043.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK004692; BAB23478.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK015059; BAB29695.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK166988; BAE39168.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK166996; BAE39175.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL844566; CAM16325.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL844573; CAM16325.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL844573; CAM19389.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL844566; CAM19389.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC024124; AAH24124.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030875; AAH30875.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC092291; AAH92291.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S65956; S65956.
RefSeq NP_666238.1; -.
UniGene Mm.371580
3D structure databases
HSSP O96496; 1E3J. [HSSP ENTRY / PDB]
SMR Q64442; 20-375.
ModBase Q64442.
PTM databases
PhosphoSite Q64442; -.
2D gel databases
REPRODUCTION-2DPAGE Q64442; -.
Organism-specific databases
MGI MGI:98266; Sord.
Gene expression databases
ArrayExpress Q64442; -.
CleanEx MM_SORD; -.
GermOnline ENSMUSG00000027227; Mus musculus.
Ontologies
GO
GO:0005625; Cellular component: soluble fraction (inferred from direct assay from MGI).
GO:0003939; Molecular function: L-iditol 2-dehydrogenase activity (inferred from direct assay from MGI).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
GO:0006060; Biological process: sorbitol metabolic process (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
ProDom PD040557; GroES_related; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00059; ADH_ZINC; 1.
ProtoNet Q64442.
Genome annotation databases
Ensembl ENSMUSG00000027227; Mus musculus. [Contig view]
GeneID 20322; -.
KEGG mmu:20322; -.
NMPDR fig|10090.3.peg.6788; -.
Phylogenomic databases
HOGENOM Q64442; -.
HOVERGEN Q64442; -.
Other
NextBio 298123; -.
SOURCE Sord; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Metal-binding; NAD; Oxidoreductase; Phosphoprotein; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   357  357     Sorbitol dehydrogenase. PRO_0000000882
METAL   45    45        Zinc; catalytic (By similarity). 
METAL   70    70        Zinc; catalytic (By similarity). 
METAL   71    71        Zinc; catalytic (By similarity). 
MOD_RES   2     2        N-acetylalanine (By similarity). 
MOD_RES   169   169        Phosphoserine. 
CONFLICT   49    49        V -> L (in Ref. 1; AAA79043). 
CONFLICT   259   259        T -> S (in Ref. 1; AAA79043). 
Sequence information
Length: 357 AA [This is the length of the unprocessed precursor] Molecular weight: 38249 Da [This is the MW of the unprocessed precursor] CRC64: FDAA462EF1EB6C21 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAPAKGENL SLVVHGPGDI RLENYPIPEL GPNDVLLKMH SVGICGSDVH YWEHGRIGDF 

        70         80         90        100        110        120 
VVKKPMVLGH EAAGTVTKVG ELVKHLKPGD RVAIEPGVPR EVDEYCKIGR YNLTPTIFFC 

       130        140        150        160        170        180 
ATPPDDGNLC RFYKHNADFC YKLPDSVTFE EGALIEPLSV GIYACRRGSV SLGNKVLVCG 

       190        200        210        220        230        240 
AGPVGMVTLL VAKAMGAAQV VVTDLSASRL TKAKEVGADF TIQVGKETPQ EIASKVESLL 

       250        260        270        280        290        300 
GSKPEVTIEC TGAESSVQTG IYATHSGGTL VIVGMGAEMV NLPLVHAAIR EVDIKGVFRY 

       310        320        330        340        350 
CNTWPMAISM LASKTLNVKP LVTHRFPLEK AVEAFETAKK GVGLKVMIKC DPNDQNP 

Q64442 in FASTA format

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