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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] OF 85-544, FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1073/pnas.91.20.9372; PubMed=7937772 [NCBI, ExPASy, EBI, Israel, Japan]
Galera P.,
Musso M.,
Ducy P.,
Karsenty G.;
"c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin.";
Proc. Natl. Acad. Sci. U.S.A. 91:9372-9376(1994).
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[3]
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FUNCTION, TISSUE SPECIFICITY, AND VARIANT HD GLY-389.
DOI=10.1038/nature03338; PubMed=15729333 [NCBI, ExPASy, EBI, Israel, Japan]
He X.,
He X.,
Dave V.P.,
Zhang Y.,
Hua X.,
Nicolas E.,
Xu W.,
Roe B.A.,
Kappes D.J.;
"The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.";
Nature 433:826-833(2005).
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- FUNCTION: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes.
- SUBCELLULAR LOCATION: Nucleus.
- TISSUE SPECIFICITY: Widely expressed, with a higher level in skin. Expressed in thymus. Restricted to CD4 cells (mature single positive CD4(+) and intermediate CD4(+)CD8(+) cells).
- DEVELOPMENTAL STAGE: Expressed, beginning at 9.5 days of gestation and at 10.5 days in regions destined to become skin. In adult animals, expression is predominantly in skin.
- DISEASE: Defects in Zbtb7b are the cause of helper deficient disease (HD). HD mice are distinguished by the virtual absence of peripheral T-cells of the CD4(+)CD8(-) major histocompatibility complex (MHC) class II-restricted T-helper subset due to a specific block in thymic development. The developmental defect is selective for CD4(+)CD8(-) cells; the maturation of CD4(-)CD8(+) and gamma delta T-cells is normal indicating that lineage commitment is specifically perturbed without affecting positive selection.
- SIMILARITY: Contains 1 BTB (POZ) domain.
- SIMILARITY: Contains 4 C2H2-type zinc fingers.
- SEQUENCE CAUTION:
- Sequence=AAA61956.1; Type=Frameshift; Positions=96, 328, 336;
- Sequence=AAA61956.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA
- Sequence=CAA85307.1; Type=Frameshift; Positions=96, 328, 336;
- Sequence=CAA85307.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 544 AA [This is the length of the unprocessed precursor] |
Molecular weight: 58918 Da [This is the MW of the unprocessed precursor] |
CRC64: 5A43F10AE2970709 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA VLAACSHYFK
70 80 90 100 110 120
KLFTEGGGGT VMGTGGGGTA SGGAGAGVCE LDFVGPEALG ALLEFAYTAT LTTSSANMPA
130 140 150 160 170 180
VLQAARLLEI PCVIAACMEI LQGSGLEAPS PDEDDCERAR QYLEAFATAT TTASTSGMPN
190 200 210 220 230 240
GEDSPPQVPL LPPPPPPPRP VARRSRKPRK AFLQTKGARA NHLVPEAPTV LTHPLTYEEE
250 260 270 280 290 300
EMVGRLGNSG GSGLGDSYSP PTGAASPAEG PLNYEVFEGE EEEEEMAYPP GYGLAQSNEP
310 320 330 340 350 360
SLSPEELGSD EDPIDPDLMA YLSSLHQDAL TPGLDGQDKL VRKRRSQMPQ ECPVCHKIIH
370 380 390 400 410 420
GAGKLPRHMR THTGEKPFAC EVCGVRFTRN DKLKIHMRKH TGERPYSCPH CPARFLHSYD
430 440 450 460 470 480
LKNHMHLHTG DRPYECHLCH KAFAKEDHLQ RHLKGQNCLE VRTRRRRKDD VAAPHYPPPS
490 500 510 520 530 540
TTTSSPAGLD LSNGHLDTFH LSLARFWEQS ATTGPPVTTQ GPPEEEEEEG TPTTPQAEGA
MESS
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Q64321 in FASTA format |
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ExPASy Home page
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