ID   AL7A1_RAT               Reviewed;         228 AA.
AC   Q64057;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   04-NOV-2008, entry version 61.
DE   RecName: Full=Alpha-aminoadipic semialdehyde dehydrogenase;
DE            Short=Alpha-AASA dehydrogenase;
DE            EC=1.2.1.31;
DE   AltName: Full=Delta1-piperideine-6-carboxylate dehydrogenease;
DE            Short=P6c dehydrogenase;
DE   AltName: Full=Aldehyde dehydrogenase family 7 member A1;
DE   AltName: Full=Antiquitin-1;
DE   Flags: Fragment;
GN   Name=Aldh7a1; Synonyms=Ald7a1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Intestinal mucosa;
RX   MEDLINE=94375061; PubMed=8088832; DOI=10.1006/geno.1994.1279;
RA   Lee P., Kuhl W., Gelbart T., Kamimura T., West C., Beutler E.;
RT   "Homology between a human protein and a protein of the green garden
RT   pea.";
RL   Genomics 21:371-378(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 25-38 AND 116-126, AND MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Spinal cord;
RA   Lubec G., Afjehi-Sadat L.;
RL   Submitted (NOV-2006) to UniProtKB.
RN   [3]
RP   TISSUE SPECIFICITY.
RX   MEDLINE=98086476; PubMed=9417906; DOI=10.1006/geno.1997.5026;
RA   Skvorak A.B., Robertson N.G., Yin Y., Weremowicz S., Her H.,
RA   Bieber F.R., Beisel K.W., Lynch E.D., Beier D.R., Morton C.C.;
RT   "An ancient conserved gene expressed in the human inner ear:
RT   identification, expression analysis, and chromosomal mapping of human
RT   and mouse antiquitin (ATQ1).";
RL   Genomics 46:191-199(1997).
CC   -!- CATALYTIC ACTIVITY: L-2-aminoadipate 6-semialdehyde + NAD(P)(+) +
CC       H(2)O = L-2-aminoadipate + NAD(P)H.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- TISSUE SPECIFICITY: Abundant in kidney, liver, cochlea and outer
CC       hair cells but not inner hair cells or vestibular type I hair
CC       cells. Very low levels in lung, brain, intestine and pancreas.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; S75019; AAB31967.2; -; mRNA.
DR   PIR; B54676; B54676.
DR   UniGene; Rn.7330; -.
DR   HSSP; P51977; 1BXS.
DR   SMR; Q64057; 1-216.
DR   Ensembl; ENSRNOG00000014645; Rattus norvegicus.
DR   RGD; 1308614; Aldh7a1.
DR   HOVERGEN; Q64057; -.
DR   ArrayExpress; Q64057; -.
DR   GermOnline; ENSRNOG00000014645; Rattus norvegicus.
DR   GO; GO:0004043; F:L-aminoadipate-semialdehyde dehydrogenase a...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016163; Ald_DHase_C.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   Gene3D; G3DSA:3.40.309.10; Aldehyde_dehydrogenase_C; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; PARTIAL.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; PARTIAL.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; NAD; Oxidoreductase.
FT   CHAIN        <1    228       Alpha-aminoadipic semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000056492.
FT   ACT_SITE     19     19       By similarity.
FT   NON_TER       1      1
SQ   SEQUENCE   228 AA;  25158 MW;  F5DA69254AF35C16 CRC64;
     SLVLPSALFA AVGTAGQRCT TVRRLFLHES IHDEVVDRLK NDYSQIRVGN PWDPNILYGP
     LHTKQAVSMF VQAVEEAKKE GGTVVYGGKV MDHPGNYVEP TIVTGLVHDA PIVHKETFAP
     ILYVFKFKNE EEVFEWNNKV KQELSSSIFT KDLGRIFRWL GPKGSDCGIV NVNIPTSGAE
     IGGAFGGEKH TGSGRESGSD AWKQYMRRST CTINYSTALP LAQGIKFQ
//