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UniProtKB/Swiss-Prot entry Q63TV1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRD_BURPS
Primary accession number Q63TV1
Secondary accession numbers None
Integrated into Swiss-Prot on August 30, 2005
Sequence was last modified on October 25, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 32)
Name and origin of the protein
Protein name Dihydroorotate dehydrogenase
Synonyms EC 1.3.3.1
Dihydroorotate oxidase
DHOdehase
DHODase
DHOD
Gene name
Name: pyrD
OrderedLocusNames: BPSL1866
From
Burkholderia pseudomallei (Pseudomonas pseudomallei) [TaxID: 28450] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; pseudomallei group.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K96243;
DOI=10.1073/pnas.0403302101; PubMed=15377794 [NCBI, ExPASy, EBI, Israel, Japan]
Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M., Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
"Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.";
Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX571965; CAH35865.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_108465.1; -.
3D structure databases
ModBase Q63TV1.
Enzyme and pathway databases
BioCyc BPSE272560:BPSL1866-MON; -.
Ontologies
GO
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from HAMAP).
GO:0004158; Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00225; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005719; DHO_DHase_2.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000164; DHO_oxidase; 1.
TIGRFAMs TIGR01036; pyrD_sub2; 1.
PROSITE PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.
BLOCKS Q63TV1.
Genome annotation databases
GeneID 3093839; -.
GenomeReviews BX571965_GR; BPSL1866.
KEGG bps:BPSL1866; -.
Phylogenomic databases
HOGENOM Q63TV1; -.
Genome annotation databases
CMR Q63TV1; BPSL1866.
Other
ProtoNet Q63TV1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Complete proteome; Flavoprotein; FMN; Membrane; Oxidoreductase; Pyrimidine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   342  342     Dihydroorotate dehydrogenase. PRO_0000148429
ACT_SITE   178   178        Nucleophile (By similarity). 
Sequence information
Length: 342 AA [This is the length of the unprocessed precursor] Molecular weight: 36323 Da [This is the MW of the unprocessed precursor] CRC64: 796E35619C05A53C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFSSLYPLAR ASLFKMDAED AHHLTLRMLG AAGRTGLACA LSPRVPDAPR TVMGLSFRNP 

        70         80         90        100        110        120 
VGLAAGLDKD GAAIDGFAAL GFGFIEVGTV TPRAQPGNPR PRMFRLPEAD AIINRMGFNN 

       130        140        150        160        170        180 
SGVDQFVKNV QAARYRGVLG LNIGKNADTP IERAADDYLY CLERVYPFAS YVTINISSPN 

       190        200        210        220        230        240 
TKNLRQLQGA GELDALLAAL KDKQRRLADL HGKLVPLALK IAPDLDDEQV KEIAATLLRH 

       250        260        270        280        290        300 
DIEGVIATNT TLSREAVKGL PHADEAGGLS GRPVFDASNA VIRKLRAELG DAVPIIGVGG 

       310        320        330        340 
IFSGEDARAK LAAGAALVQL YTGFIYRGPA LVAECVKAIA RG 

Q63TV1 in FASTA format

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