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UniProtKB/Swiss-Prot entry Q63QF1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEM1_BURPS
Primary accession number Q63QF1
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 2005
Sequence was last modified on October 25, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 32)
Name and origin of the protein
Protein name Glutamyl-tRNA reductase
Synonyms GluTR
EC 1.2.1.70
Gene name
Name: hemA
OrderedLocusNames: BPSL3072
From
Burkholderia pseudomallei (Pseudomonas pseudomallei) [TaxID: 28450] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; pseudomallei group.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K96243;
DOI=10.1073/pnas.0403302101; PubMed=15377794 [NCBI, ExPASy, EBI, Israel, Japan]
Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M., Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A., Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S., Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M., Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
"Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.";
Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX571965; CAH37083.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_109667.2; -.
3D structure databases
ModBase Q63QF1.
Enzyme and pathway databases
BioCyc BPSE272560:BPSL3072-MON; -.
Ontologies
GO
GO:0008883; Molecular function: glutamyl-tRNA reductase activity (inferred from electronic annotation from HAMAP).
GO:0006779; Biological process: porphyrin biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00087; -; 1.
PBIL [Tree]
InterPro IPR000343; 4pyrrol_synth_GluRdtase.
IPR015896; 4pyrrol_synth_GluRdtase_C.
IPR015895; 4pyrrol_synth_GluRdtase_N.
IPR016040; NAD(P)-bd.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00745; GlutR_dimer; 1.
PF05201; GlutR_N; 1.
PF01488; Shikimate_DH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000445; 4pyrrol_synth_GluRdtase; 1.
TIGRFAMs TIGR01035; hemA; 1.
PROSITE PS00747; GLUTR; 1.
BLOCKS Q63QF1.
Genome annotation databases
GeneID 3094369; -.
GenomeReviews BX571965_GR; BPSL3072.
KEGG bps:BPSL3072; -.
Phylogenomic databases
HOGENOM Q63QF1; -.
Genome annotation databases
CMR Q63QF1; BPSL3072.
Other
ProtoNet Q63QF1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase; Porphyrin biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   441  441     Glutamyl-tRNA reductase. PRO_0000114001
NP_BIND   203   208  6     NADP (By similarity). 
REGION   64    67  4     Substrate binding (By similarity). 
REGION   128   130  3     Substrate binding (By similarity). 
ACT_SITE   65    65        Nucleophile (By similarity). 
BINDING   123   123        Substrate (By similarity). 
BINDING   134   134        Substrate (By similarity). 
SITE   113   113  1     Important for activity (By similarity). 
Sequence information
Length: 441 AA [This is the length of the unprocessed precursor] Molecular weight: 48258 Da [This is the MW of the unprocessed precursor] CRC64: 06D2A7C3C3F1D032 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGLNDSLLDM QLLTIGINHH TAPVALRERV AFPLEQIKPA LSTFKSVFLG HPAPNAPEAA 

        70         80         90        100        110        120 
ILSTCNRTEL YCATNDRAAR DAAIRWMSDY HRIPADELAP HVYALPQSEA VRHAFRVASG 

       130        140        150        160        170        180 
LDSMVLGETQ ILGQMKNAVR TASEAGSLGT YLNQLFQRTF AVAKEVRGTT EIGAQSVSMA 

       190        200        210        220        230        240 
AAAVRLAQRI FEQVAQQRVL FIGAGEMIEL CATHFAAQGP RELVVANRTA ERGAKLAERF 

       250        260        270        280        290        300 
GGRAMPLADL PARMHEFDII VSCTASTLPI IGLGAVERAV KARRHRPIFM VDLAVPRDIE 

       310        320        330        340        350        360 
PEVGKLKDVF LYTVDDLGAI VREGNASRQA AVAQAEAIIE TRVQNFMQWL DARSIVPVIR 

       370        380        390        400        410        420 
HMHTQADALR RAEVERARKM LARGDDPDAV LDALSQALTN KLIHGPTSAL NRANGADRDS 

       430        440 
LIDLMRGFYQ HAPRSSDTSD R 

Q63QF1 in FASTA format

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