ID   BETB_BURPS              Reviewed;         489 AA.
AC   Q63KK8;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   04-NOV-2008, entry version 31.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betB; OrderedLocusNames=BPSS1354;
OS   Burkholderia pseudomallei (Pseudomonas pseudomallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=28450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L.,
RA   Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R.,
RA   Brooks K., Brown K.A., Brown N.F., Challis G.L., Cherevach I.,
RA   Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D.,
RA   Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K.,
RA   Keith K.E., Maddison M., Moule S., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M.,
RA   Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis,
RT   Burkholderia pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; BX571966; CAH38825.1; -; Genomic_DNA.
DR   RefSeq; YP_111364.1; -.
DR   GeneID; 3096019; -.
DR   GenomeReviews; BX571966_GR; BPSS1354.
DR   KEGG; bps:BPSS1354; -.
DR   HOGENOM; Q63KK8; -.
DR   BioCyc; BPSE272560:BPSS1354-MON; -.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR011264; Betaine_Ald_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    489       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_0000056540.
FT   NP_BIND     228    233       NAD (By similarity).
FT   ACT_SITE    251    251       By similarity.
FT   ACT_SITE    285    285       By similarity.
SQ   SEQUENCE   489 AA;  52211 MW;  0373B97C34DA69F5 CRC64;
     MSVYGLQRLY IAGAHADATS GKTFDTFDPA TGELLARVQQ ASADDVDRAV ASAREGQREW
     AAMTAMQRSR ILRRAVELLR ERNDALAELE MRDTGKPIAE TRAVDIVTGA DVIEYYAGLA
     TAIEGLQVPL RPESFVYTRR EPLGVCAGIG AWNYPIQIAC WKSAPALAAG NAMIFKPSEV
     TPLSALKLAE IYTEAGVPAG VFNVVQGDGS VGALLSAHPG IAKVSFTGGV ETGKKVMSLA
     GASSLKEVTM ELGGKSPLIV FDDADLDRAA DIAVTANFFS AGQVCTNGTR VFVQQAVKDA
     FVERVLARVA RIRVGKPSDP DTNFGPLASA AQLDKVLGYI DSGKAEGAKL LAGGARLVND
     HFASGQYVAP TVFGDCRDDM RIVREEIFGP VMSILPFETE DEAIARANAT DYGLAAGVVT
     ENLSRAHRAI HRLEAGICWI NTWGESPAEM PVGGYKQSGV GRENGITTLE HYTRIKSVQV
     ELGRYQPVF
//