ID   BETA_BURPS              Reviewed;         565 AA.
AC   Q63KK7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-NOV-2008, entry version 35.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=BPSS1355;
OS   Burkholderia pseudomallei (Pseudomonas pseudomallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=28450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L.,
RA   Bentley S.D., Sebaihia M., Thomson N.R., Bason N., Beacham I.R.,
RA   Brooks K., Brown K.A., Brown N.F., Challis G.L., Cherevach I.,
RA   Chillingworth T., Cronin A., Crossett B., Davis P., DeShazer D.,
RA   Feltwell T., Fraser A., Hance Z., Hauser H., Holroyd S., Jagels K.,
RA   Keith K.E., Maddison M., Moule S., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K., Sanders M., Simmonds M.,
RA   Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis,
RT   Burkholderia pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; BX571966; CAH38826.1; -; Genomic_DNA.
DR   RefSeq; YP_111365.1; -.
DR   GeneID; 3096018; -.
DR   GenomeReviews; BX571966_GR; BPSS1355.
DR   KEGG; bps:BPSS1355; -.
DR   NMPDR; fig|272560.3.peg.1381; -.
DR   HOGENOM; Q63KK7; -.
DR   BioCyc; BPSE272560:BPSS1355-MON; -.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    565       Choline dehydrogenase.
FT                                /FTId=PRO_0000258919.
FT   NP_BIND       7     36       FAD (Probable).
FT   ACT_SITE    474    474       By similarity.
SQ   SEQUENCE   565 AA;  62703 MW;  6990A10A40FD48C0 CRC64;
     MTTREFDYII CGAGSAGNVL ATRLTEDPGV TVLLLEAGGP DYRFDFRTQM PAALAYPLQG
     RRYNWAYETD PEPHMNHRRM ECGRGKGLGG SSLINGMCYI RGNALDYDNW ATHKALEDWA
     YLDCLPYFRK AETRDVGPND YHGGDGPVSV TTSKPGVNPL FEAMVEAGVQ AGYPRTDDLN
     GYQQEGFGPM DRTVTPRGRR ASTARGYLDQ ARARPNLEIV THALADRILF SGKRATGVTF
     LHGSARVTAH ARREVLVCSG AIASPQLLQR SGVGPGEWLR ELDIPVVLDL PGVGRNLQDH
     LEMYIQFECK EPVSLYPALK WWNQPKIGLE WMLNGTGLGA SNHFEAGGFI RTRDDDPWPN
     IQYHFLPVAI NYNGSNAIEM HGFQAHVGSM RSPSRGRVKL KSRDPHAHPS ILFNYMAEAL
     DWREFRDAIR ATREIMRQPA LDRFRGRELN PGADLKSDNE LDTFVRARAE TAFHPSCSCK
     MGYDDMAVVD NEGRVHGIDG LRVVDASIMP IITTGNLNAP TIMIAEKIAD RIRQHKPLER
     SNAQYYVANG APARGGKPAR APAVV
//