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UniProtKB/Swiss-Prot entry Q62893


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AMHR2_RAT
Primary accession number Q62893
Secondary accession numbers Q63045 Q9R0A7
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 75)
Name and origin of the protein
Protein name Anti-Muellerian hormone type-2 receptor [Precursor]
Synonyms EC 2.7.11.30
Anti-Muellerian hormone type II receptor
AMH type II receptor
MIS type II receptor
MISRII
MRII
C14
Gene name
Name: Amhr2
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1210/en.137.1.160; PubMed=8536608 [NCBI, ExPASy, EBI, Israel, Japan]
Teixeira J., He W.W., Shah P.C., Morikawa N., Lee M.M., Catlin E.A., Hudson P.L., Wing J., Maclaughlin D.T., Donahoe P.K.;
"Developmental expression of a candidate Muellerian inhibiting substance type II receptor.";
Endocrinology 137:160-165(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
PubMed=8119126 [NCBI, ExPASy, EBI, Israel, Japan]
Baarends W.M., Van Helmond M.J.L., Post M., Van der Schoot P.J.C.M., Hoogerbrugge J.W., de Winter J.P., Uilenbroek J.T.J., Karels B., Wilming L.G., Meijers J.H.C., Themmem A.P.N., Grootegoed A.J.;
"A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the Muellerian duct.";
Development 120:189-197(1994).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.
STRAIN=Sprague-Dawley;
DOI=10.1073/pnas.96.24.13831; PubMed=10570158 [NCBI, ExPASy, EBI, Israel, Japan]
Teixeira J., Kehas D.J., Antun R., Donahoe P.K.;
"Transcriptional regulation of the rat Muellerian inhibiting substance type II receptor in rodent Leydig cells.";
Proc. Natl. Acad. Sci. U.S.A. 96:13831-13838(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U42427; AAC52343.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X71916; CAA50731.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF092445; AAC64138.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S41627; S41627.
RefSeq NP_112260.1; -.
UniGene Rn.10165
3D structure databases
HSSP P36897; 1IAS. [HSSP ENTRY / PDB]
ModBase Q62893.
Organism-specific databases
RGD 70964; Amhr2.
Gene expression databases
ArrayExpress Q62893; -.
GermOnline ENSRNOG00000014850; Rattus norvegicus.
Ontologies
GO
GO:0042562; Molecular function: hormone binding (inferred from sequence or structural similarity from UniProtKB).
GO:0004872; Molecular function: receptor activity (inferred from sequence or structural similarity from UniProtKB).
GO:0007548; Biological process: sex differentiation (inferred from sequence or structural similarity from UniProtKB).
GO:0007165; Biological process: signal transduction (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR017193; Anti-muellerian_hrmn_rcpt_II.
IPR015771; Anti-muellerian_hrmn_rcpt_II_C.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
Graphical view of domain structure.
PANTHER PTHR23255:SF4; MIS_II_R; 1.
Pfam PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF037392; AMHRII; 1.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q62893.
Genome annotation databases
Ensembl ENSRNOG00000014850; Rattus norvegicus. [Contig view]
GeneID 29530; -.
KEGG rno:29530; -.
Phylogenomic databases
HOVERGEN Q62893; -.
Other
ProtoNet Q62893.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    17  17     Potential. 
CHAIN   18   557  540     Anti-Muellerian hormone type-2 receptor. PRO_0000024409
TOPO_DOM   18   144  127     Extracellular (Potential). 
TRANSMEM   145   165  21     Potential. 
TOPO_DOM   166   557  392     Cytoplasmic (Potential). 
DOMAIN   201   511  311     Protein kinase. 
NP_BIND   207   215  9     ATP (By similarity). 
ACT_SITE   331   331        Proton acceptor (By similarity). 
BINDING   228   228        ATP (By similarity). 
CARBOHYD   66    66        N-linked (GlcNAc...) (Potential). 
CARBOHYD   119   119        N-linked (GlcNAc...) (Potential). 
CONFLICT   527   527        C -> Y (in Ref. 2; CAA50731). 
Sequence information
Length: 557 AA [This is the length of the unprocessed precursor] Molecular weight: 59749 Da [This is the MW of the unprocessed precursor] CRC64: 8EDEE9C0C32EBDD5 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP KGIRCLYSHC 

        70         80         90        100        110        120 
CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP SPSSTLFTCS CGTDFCNANY 

       130        140        150        160        170        180 
SHLPPSGNRG APGPQEPQAT PGGPIWMAQL LLGVFLVLLL SIIILALLQR KACRVQGGSD 

       190        200        210        220        230        240 
PEPEPGSGGD CSEELPELAE LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA 

       250        260        270        280        290        300 
ERAVYQLLGL QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL 

       310        320        330        340        350        360 
RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL GLALVLPGLA 

       370        380        390        400        410        420 
QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG TALQRADVYS LALLLWEILS 

       430        440        450        460        470        480 
RCSDLRPDHR PPPFQLAYEA ELGSNPSACE LWALAVAERK RPNIPSSWSC SATDPRGLRE 

       490        500        510        520        530        540 
LLEDCWDADP EARLTAECVQ QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP 

       550 
QQSSCLLSVQ QGSGSKS 

Q62893 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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