[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain cortex; Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.; "Isolation and characterization of cDNA for macaque neurological disease genes."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side (By similarity).
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB125149; BAD51937.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q60HH8.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR012394; Ald_DHase_NAD(P).
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF15; ALDH; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF036492; ALDH; 1.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

Q60HH8.

Phylogenomic databases

HOVERGEN

Q60HH8; -.

Other

ProtoNet

Q60HH8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; Membrane; NAD; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 485`	`485`	`Fatty aldehyde dehydrogenase.`	`PRO_0000056474`
`TOPO_DOM`	`1 463`	`463`	`Cytoplasmic.`
`TRANSMEM`	`464 480`	`17`	`Potential.`
`NP_BIND`	`185 190`	`6`	`NAD (Potential).`
`MOTIF`	`481 484`	`4`	`Prevents secretion from ER (By similarity).`
`ACT_SITE`	`207 207`		`By similarity.`
`ACT_SITE`	`241 241`		`By similarity.`

Sequence information

Length: 485 AA [This is the length of the unprocessed precursor]

Molecular weight: 54628 Da [This is the MW of the unprocessed precursor]

CRC64: D01B965D56CBF3D6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEREVQRVRQ AFLSGRSRPL RFRLQQLEAL RRMVQEREKD ILAAIAADLC KSELNAYSQE 

        70         80         90        100        110        120 
VITVLGEIDF MLENLPEWVT AKPVKKNLLT MMDEAYIQPQ PLGVVLIIGA WNYPFVLIIQ 

       130        140        150        160        170        180 
PLIGAIAAGN AVIIKPSELS ENTAKIVAKL LPQYLDQDLY VVINGGVEET TELLKQRFDH 

       190        200        210        220        230        240 
IFYTGNTAVG KIVMEAAAKH LTPVTLELGG KSPCYIDKDC DLDIVCRRIT WGKYMNCGQT 

       250        260        270        280        290        300 
CIAPDYILCE ASLQSQIVWK IKETVKEFYG ENIKESPDYE RIINLRHFKR ILSLLEGQKI 

       310        320        330        340        350        360 
ALGGETDEAT RYIAPTVLTD VDPKTKVMQE EIFGPVLPIV PVKNVDEATD FINEREKPLA 

       370        380        390        400        410        420 
LYVFSHNHKL IKRMIDETSS GGVTGNDVIM HFTLNSFPFG GVGSSGMGAY HGKHSFDTFS 

       430        440        450        460        470        480 
HQRPCLLKSL KREGANKLRY PPNSQSKVDW GKFFLLRRFN KEKLGLLVLT FLGIVAAVLV 


NAGYY

Q60HH8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools