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UniProtKB/Swiss-Prot entry Q60080

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHAS_VIBMI
Primary accession number Q60080
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 45)
Name and origin of the protein
Protein name Aspartate-semialdehyde dehydrogenase [Fragment]
Synonyms ASA dehydrogenase
ASADH
EC 1.2.1.11
Gene name
Name: asd
From
Vibrio mimicus [TaxID: 674] 
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=M547;
PubMed=7768818 [NCBI, ExPASy, EBI, Israel, Japan]
Karaolis D.K., Lan R., Reeves P.R.;
"The sixth and seventh cholera pandemics are due to independent clones separately derived from environmental, nontoxigenic, non-O1 Vibrio cholerae.";
J. Bacteriol. 177:3191-3198(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U25067; AAC43377.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase Q60080.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0004073; Molecular function: aspartate-semialdehyde dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0050661; Molecular function: NADP binding (inferred from electronic annotation from InterPro).
GO:0046983; Molecular function: protein dimerization activity (inferred from electronic annotation from InterPro).
GO:0019877; Biological process: diaminopimelate biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0009086; Biological process: methionine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0009088; Biological process: threonine biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000319; Asp-semialdehyde_DHase_CS.
IPR012080; Asp_semialdehyde_DHase.
IPR005986; Asp_semialdehyde_DHase_bac.
IPR000534; Semialdehyde_DHase_NAD-bd.
IPR012280; Semialdhyde_DHase_C.
Graphical view of domain structure.
Pfam PF01118; Semialdhyde_dh; 1.
PF02774; Semialdhyde_dhC; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000148; ASA_dh; 1.
TIGRFAMs TIGR01296; asd_B; 1.
PROSITE PS01103; ASD; 1.
Other
ProtoNet Q60080.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Diaminopimelate biosynthesis; Lysine biosynthesis; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   >316  >316     Aspartate-semialdehyde dehydrogenase. PRO_0000141395
ACT_SITE   132    132        Acyl-thioester intermediate (By similarity). 
NON_TER   316    316         
Sequence information
Length: 316 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 35139 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: 5E27AFAD9BC63A11 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSQQFNVAIF GATGAVGETM LEVLQEREFP VDELFLLASE RSEGKTYRFN GKTVRVQNVE 

        70         80         90        100        110        120 
EFDWSQVHIA LFSAGGELSA HWAPIRAEAG VVVIDNTSHF RYDYDIPLVI PEVNPEAIAE 

       130        140        150        160        170        180 
FRNRNIIANP NCSTIQMLVA LKPIYDAVGI ERINVTTYQS VSGAGKAGID ELAGQTAKLL 

       190        200        210        220        230        240 
NGYPAETNTF SQQIAFNCIP QIDQFMDNGY TKEEMKMVWE TQKIFNDPSI MVNPTCVRVP 

       250        260        270        280        290        300 
VFYGHAEAVH VETRAPIDAE QVMDMLDQTD GIELFRGADF PTQVRDAGGK DHVLVGRVRN 

       310 
DISHHSGVNL WVVADN
Q60080 in FASTA format

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