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UniProtKB/Swiss-Prot entry Q5ZT84


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LLY_LEGPH
Primary accession number Q5ZT84
Secondary accession number Q53407
Integrated into Swiss-Prot on February 1, 2005
Sequence was last modified on February 1, 2005 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 24)
Name and origin of the protein
Protein name 4-hydroxyphenylpyruvate dioxygenase
Synonyms HPPDase
4HPPD
HPD
EC 1.13.11.27
Legiolysin
Gene name
Name: lly
Synonyms: hpd
OrderedLocusNames: lpg2278
From
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [TaxID: 272624] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Legionellaceae; Legionella.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
PubMed=8112844 [NCBI, ExPASy, EBI, Israel, Japan]
Wintermeyer E., Flugel M., Ott M., Steinert M., Rdest U., Mann K.H., Hacker J.;
"Sequence determination and mutational analysis of the lly locus of Legionella pneumophila.";
Infect. Immun. 62:1109-1117(1994).
[2]
SEQUENCE REVISION TO 94, AND CHARACTERIZATION.
Flugel M., Steinert M., Wintermeyer E., Supriyono A., Proksch P., Hacker J.;
"Homogentisic acid is a product of the p-hydroxyphenylpyruvate dioxygenase activity of the Lly-protein, which mediates melanogenesis in Legionella pneumophila.";
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1099776; PubMed=15448271 [NCBI, ExPASy, EBI, Israel, Japan]
Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J.;
"The genomic sequence of the accidental pathogen Legionella pneumophila.";
Science 305:1966-1968(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF075724; AAC32843.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE017354; AAU28343.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_096290.1; -.
3D structure databases
HSSP P80064; 1CJX. [HSSP ENTRY / PDB]
ModBase Q5ZT84.
Enzyme and pathway databases
BioCyc LPNE272624:LPG2278-MON; -.
Family and domain databases
InterPro IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.
PANTHER PTHR11959; HPP_dOase; 1.
Pfam PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF009283; HPP_dOase; 1.
TIGRFAMs TIGR01263; 4HPPD; 1.
BLOCKS Q5ZT84.
Genome annotation databases
GeneID 3079183; -.
GenomeReviews AE017354_GR; lpg2278.
KEGG lpn:lpg2278; -.
Phylogenomic databases
HOGENOM Q5ZT84; -.
Genome annotation databases
CMR Q5ZT84; lpg2278.
Other
ProtoNet Q5ZT84.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytolysis; Dioxygenase; Direct protein sequencing; Hemolysis; Iron; Metal-binding; Oxidoreductase; Toxin.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   348  348     4-hydroxyphenylpyruvate dioxygenase. PRO_0000088412
METAL   154   154        Iron (By similarity). 
METAL   232   232        Iron (By similarity). 
METAL   312   312        Iron (By similarity). 
Sequence information
Length: 348 AA [This is the length of the unprocessed precursor] Molecular weight: 38923 Da [This is the MW of the unprocessed precursor] CRC64: DA822AAFB019DB8F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQNNNPCGLD GFAFLEFSGP DRNKLHQQFS EMGFQAVAHH KNQDITLFKQ GEIQFIVNAA 

        70         80         90        100        110        120 
SHCQAEAHAS THGPGACAMG FKVKDAKAAF QHAIAHGGIA FQDAPHANHG LPAIQAIGGS 

       130        140        150        160        170        180 
VIYFVDEEHQ PFSHEWNITS PEPVVGNGLT AIDHLTHNVY RGNMDKWASF YASIFNFQEI 

       190        200        210        220        230        240 
RFFNIKGKMT GLVSRALGSP CGKIKIPLNE SKDDLSQIEE FLHEYHGEGI QHIALNTNDI 

       250        260        270        280        290        300 
YKTVNGLRKQ GVKFLDVPDT YYEMINDRLP WHKEPLNQLH AEKILIDGEA DPKDGLLLQI 

       310        320        330        340 
FTENIFGPVF FEIIQRKGNQ GFGEGNFQAL FEAIERDQVR RGTLKELS 

Q5ZT84 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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