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UniProtKB/Swiss-Prot entry Q5ZLR5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UCRI_CHICK
Primary accession number Q5ZLR5
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 2008
Sequence was last modified on November 23, 2004 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 28)
Name and origin of the protein
Protein name Cytochrome b-c1 complex subunit Rieske, mitochondrial [Precursor]
Synonyms EC 1.10.2.2
Ubiquinol-cytochrome c reductase iron-sulfur subunit
Rieske iron-sulfur protein
RISP
Complex III subunit 5
Gene name
Name: UQCRFS1
ORFNames: RCJMB04_5b19
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=CB;
TISSUE=Bursa of Fabricius;
DOI=10.1186/gb-2004-6-1-r6; PubMed=15642098 [NCBI, ExPASy, EBI, Israel, Japan]
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.";
Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005).
Comments
  • FUNCTION: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity).
  • CATALYTIC ACTIVITY: QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H+.
  • COFACTOR: Binds 1 2Fe-2S cluster per subunit (By similarity).
  • SUBUNIT: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9 and UQCR11/QCR10) (By similarity).
  • SUBCELLULAR LOCATION: Mitochondrion inner membrane (By similarity).
  • MISCELLANEOUS: The Rieske protein is a high potential 2Fe-2S protein.
  • SIMILARITY: Contains 1 Rieske domain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ719669; CAG31328.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001005843.1; -.
UniGene Gga.5791
3D structure databases
SMR Q5ZLR5; 78-272.
ModBase Q5ZLR5.
Family and domain databases
InterPro IPR014349; Rieske.
IPR005805; Rieske_C.
IPR006317; Rieske_proteo.
IPR005806; Rieske_reg.
IPR015248; Ubiq_cytc_red_N.
IPR004192; UCR_TM_region.
Graphical view of domain structure.
Gene3D G3DSA:2.102.10.10; Rieske_reg; 1.
PANTHER PTHR10134; Rieske; 1.
Pfam PF00355; Rieske; 1.
PF09165; Ubiq-Cytc-red_N; 1.
PF02921; UCR_TM; 1.
Pfam graphical view of domain structure.
PRINTS PR00162; RIESKE.
TIGRFAMs TIGR01416; Rieske_proteo; 1.
PROSITE PS51296; RIESKE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q5ZLR5.
Genome annotation databases
Ensembl ENSGALG00000004452; Gallus gallus. [Contig view]
GeneID 415752; -.
KEGG gga:415752; -.
Phylogenomic databases
HOVERGEN Q5ZLR5; -.
Other
ProtoNet Q5ZLR5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
2Fe-2S; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Respiratory chain; Transit peptide; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    76  76     Mitochondrion (By similarity). 
CHAIN   77   272  196     Cytochrome b-c1 complex subunit Rieske, mitochondrial. PRO_0000342403
DOMAIN   185   270  86     Rieske. 
METAL   215   215        Iron-sulfur (2Fe-2S) (By similarity). 
METAL   217   217        Iron-sulfur (2Fe-2S); via pros nitrogen (By similarity). 
METAL   234   234        Iron-sulfur (2Fe-2S) (By similarity). 
METAL   237   237        Iron-sulfur (2Fe-2S); via pros nitrogen (By similarity). 
DISULFID   220   236        By similarity. 
Sequence information
Length: 272 AA [This is the length of the unprocessed precursor] Molecular weight: 29387 Da [This is the MW of the unprocessed precursor] CRC64: 3E60AD2419D26C25 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLSVAARSGP FAPYLSAAAH AVPGPLKALA PAALRAEKVV LDLKRPLLCR ESMSGRSARR 

        70         80         90        100        110        120 
DLVAGISLNA PASVRYVHND VTVPDFSAYR REDVMDATTS SQTSSEDRKG FSYLVTATAC 

       130        140        150        160        170        180 
VATAYAAKNV VTQFISSLSA SADVLALSKI EIKLSDIPEG KNVAFKWRGK PLFVRHRTQA 

       190        200        210        220        230        240 
EINQEAEVDV SKLRDPQHDL DRVKKPEWVI LVGVCTHLGC VPIANSGDFG GYYCPCHGSH 

       250        260        270 
YDASGRIRKG PAPYNLEVPT YQFVGDDLVV VG 

Q5ZLR5 in FASTA format

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