NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=CB;
TISSUE=Bursa of Fabricius;
DOI=10.1186/gb-2004-6-1-r6; PubMed=15642098 [NCBI, ExPASy, EBI, Israel, Japan]
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.";
Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005).

Comments

CATALYTIC ACTIVITY: (R)-3-hydroxybutanoate + NAD⁺ = acetoacetate + NADH.
ENZYME REGULATION: Requires phosphatidylcholine as an allosteric activator for enzymatic activity (By similarity).
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ720289; CAG31948.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001006547.1; -.

UniGene

Gga.5444

3D structure databases

ModBase

Q5ZJZ5.

Ontologies

GO:0005759;	Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0003858;	Molecular function: 3-hydroxybutyrate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR19410; ADH_short_C2; 1.

Pfam

PF00106; adh_short; 1.
Pfam graphical view of domain structure.

PRINTS

PR00081; GDHRDH.
PR00080; SDRFAMILY.

PROSITE

PS00061; ADH_SHORT; 1.

Genome annotation databases

Ensembl

ENSGALG00000006947; Gallus gallus. [Contig view]

GeneID

424891; -.

KEGG

gga:424891; -.

Phylogenomic databases

HOGENOM

Q5ZJZ5; -.

HOVERGEN

Q5ZJZ5; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Allosteric enzyme; Mitochondrion; NAD; Oxidoreductase; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 46`	`46`	`Mitochondrion (By similarity).`
`CHAIN`	`47 339`	`293`	`D-beta-hydroxybutyrate dehydrogenase, mitochondrial.`	`PRO_0000031963`
`ACT_SITE`	`204 204`		`Proton acceptor (By similarity).`
`BINDING`	`191 191`		`Substrate (By similarity).`

Sequence information

Length: 339 AA [This is the length of the unprocessed precursor]

Molecular weight: 38237 Da [This is the MW of the unprocessed precursor]

CRC64: 208BADB539C6F108 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLATKLSRPL LNLPVKTLTV KNPGNSFRPV QRFCFPLLSS CGSRSYASEV DQIGSRAVLT 

        70         80         90        100        110        120 
LGLDLPWPKH LHTKGFIIYA GCLQKNKGEG GSKDLDNMNS DRMRTVQLNV CDSKEVDRAV 

       130        140        150        160        170        180 
EHVNSSLEDP EKGLWGLVNN AGISTFGEVE FTSMDTYMEV AEVNLWGTVR TTKAFLPLIR 

       190        200        210        220        230        240 
RSKGRVVNIS SMMGRMGSPA RSPYCITKFG VEAFSDCLRY EMQPQGVMVS IVEPGNFIAV 

       250        260        270        280        290        300 
TNLYSPERIK AIADKMWDEL PEIVRKDYGR KYFDEQVSKM ETYCNSGSTD TSPVIESVAH 

       310        320        330 
ALTSTAPYTR YHPMDYYWWL RMQIMTHMPA AISDRLYVY

Q5ZJZ5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools