[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=cv. Nipponbare; The international rice genome sequencing project (IRGSP) consortium; "Oryza sativa nipponbare chromosome 6 genomic DNA sequence."; Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=cv. Nipponbare; DOI=10.1126/science.1081288; PubMed=12869764 [NCBI, ExPASy, EBI, Israel, Japan] The rice full-length cDNA consortium; "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."; Science 301:376-379(2003).

Comments

FUNCTION: Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis (By similarity).
CATALYTIC ACTIVITY: Myo-inositol + O₂ = D-glucuronate + H₂O.
COFACTOR: Binds 2 iron ions per subunit (By similarity).
PATHWAY: Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the myo-inositol oxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP003713; BAD53740.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AP003762; BAD53821.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK068862; -; NOT_ANNOTATED_CDS; mRNA.	[EMBL / GenBank / DDBJ]

RefSeq

NP_001057871.1; -.

UniGene

Os.6345

3D structure databases

ModBase

Q5Z8T3.

Organism-specific databases

Gramene

Q5Z8T3; -.

Ontologies

GO:0050113;	Molecular function: inositol oxygenase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR007828; DUF706.
Graphical view of domain structure.

PANTHER

PTHR12588; DUF706; 1.

Pfam

PF05153; DUF706; 1.
Pfam graphical view of domain structure.

BLOCKS

Q5Z8T3.

Genome annotation databases

GeneID

4341305; -.

KEGG

osa:4341305; -.

Other

ProtoNet

Q5Z8T3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Ascorbate biosynthesis; Cytoplasm; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 308`	`308`	`Probable inositol oxygenase.`	`PRO_0000079158`
`METAL`	`119 119`		`Iron 1 (By similarity).`
`METAL`	`144 144`		`Iron 1 (By similarity).`
`METAL`	`145 145`		`Iron 1 (By similarity).`
`METAL`	`145 145`		`Iron 2 (By similarity).`
`METAL`	`217 217`		`Iron 2 (By similarity).`
`METAL`	`243 243`		`Iron 2 (By similarity).`
`METAL`	`276 276`		`Iron 1 (By similarity).`

Sequence information

Length: 308 AA [This is the length of the unprocessed precursor]

Molecular weight: 35805 Da [This is the MW of the unprocessed precursor]

CRC64: 7612DA5BFA7DE5FF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTITIEQPHL DAIADRKVAG GGGGDNAAEL VLDGGFVVPD SNAFGNAFRN YEAESERKET 

        70         80         90        100        110        120 
VEEFYRVNHI NQTYDFVRRM REEYGRVDKT EMGIWECIEL LNEFIDDSDP DLDMPQIEHL 

       130        140        150        160        170        180 
LQTAEAIRKD FPDEDWLHLT GLIHDLGKVL LHPSFGELPQ WSVVGDTFPV GCAFDECNVH 

       190        200        210        220        230        240 
FKYFKENPDY LNPKLNTKFG AYSEGCGLDN VLMSWGHDDY MYLVAKENKT TLPSAGLFII 

       250        260        270        280        290        300 
RYHSFYPLHK HGAYMHLMND EDKENLKWLR VFNKYDLYSK SNERIDVEKV KPYYMSLIEK 


YFPAKLRW

Q5Z8T3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools