NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-946 / MGAS10394 / Serotype M6;
DOI=10.1086/422697; PubMed=15272401 [NCBI, ExPASy, EBI, Israel, Japan]
Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E., Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
"Progress toward characterization of the group A Streptococcus metagenome: complete genome sequence of a macrolide-resistant serotype M6 strain.";
J. Infect. Dis. 190:727-738(2004).

Comments

CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + O₂ = glycerone phosphate + H₂O₂.
COFACTOR: FAD (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
CAUTION: As S.pyogenes is unable to produce acid from glycerol, the significance and/or function of the glpO gene in this organism is at present unknown.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000003; AAT87563.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_060746.1; -.

3D structure databases

ModBase

Q5XAK0.

Enzyme and pathway databases

BioCyc

SPYO286636:M6_SPY1428-MON; -.

Family and domain databases

InterPro

IPR000447; FAD-dep_Gly3P_DHase.
IPR006076; FAD-dep_OxRdtase.
Graphical view of domain structure.

Pfam

PF01266; DAO; 1.
Pfam graphical view of domain structure.

PRINTS

PR01001; FADG3PDH.

PROSITE

PS00977; FAD_G3PDH_1; 1.
PS00978; FAD_G3PDH_2; FALSE_NEG.

BLOCKS

Q5XAK0.

Genome annotation databases

GeneID

2941714; -.

GenomeReviews

CP000003_GR; M6_Spy1428.

KEGG

spa:M6_Spy1428; -.

Phylogenomic databases

HOGENOM

Q5XAK0; -.

Genome annotation databases

CMR

Q5XAK0; M6_Spy1428.

Other

ProtoNet

Q5XAK0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; FAD; Flavoprotein; Glycerol metabolism; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 612`	`612`	`Alpha-glycerophosphate oxidase.`	`PRO_0000126112`
`NP_BIND`	`21 49`	`29`	`FAD (Potential).`

Sequence information

Length: 612 AA [This is the length of the unprocessed precursor]

Molecular weight: 67914 Da [This is the MW of the unprocessed precursor]

CRC64: 341CDF7964357A57 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEFSKETRRL ALQKMQERDL DLLIIGGGIT GAGVALQAAA SGLDTGLIEM QDFAEGTSSR 

        70         80         90        100        110        120 
STKLVHGGLR YLKQFDVEVV SDTVSERAVV QQIAPHIPKP DPMLLPVYDE PGSTFSMFRL 

       130        140        150        160        170        180 
KVAMDLYDLL AGVSNTPAAN KVLTKEEVLK REPDLKQEGL LGGGVYLDFR NNDARLVIEN 

       190        200        210        220        230        240 
IKRANRDGAL IASHVKAEDF LLDDKRQIIG VKARDLLTDQ EIIIKAKLVI NTTGPWSDEI 

       250        260        270        280        290        300 
RQFSHKGQPI HQMRPTKGVH LVVDRQKLPV SQPVYVDTGL NDGRMVFVLP REEKTYFGTT 

       310        320        330        340        350        360 
DTDYTGDLQH PQVTQEDVDY LLGIVNNRFP NANLTINDIE SSWAGLRPLL SGNSASDYNG 

       370        380        390        400        410        420 
GNSGKLSDDS FDHLIDTVKA YINHEDSREA VEKAIKQVET STSEKELDPS AVSRGSSFER 

       430        440        450        460        470        480 
DENGLFTLAG GKITDYRKMA EGALKVIIQV LKEDFGKSFK LINSTTYPVS GGEINPANVD 

       490        500        510        520        530        540 
SELEAYAQLG TLSGLSMDDA RYLANLYGSN APKVFALTRQ LKAAEGLSLA ETLSLHYAMD 

       550        560        570        580        590        600 
YEMALKPTDY FLRRTNHLLF MRDSLDALIV PVIEEMAKHF DWSTDEKVKQ EEELRRVIAE 

       610 
NDLSALKGQQ ED

Q5XAK0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools