NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/ng1447; PubMed=15467720 [NCBI, ExPASy, EBI, Israel, Japan]
Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.;
"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity.";
Nat. Genet. 36:1165-1173(2004).

Comments

FUNCTION: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate (By similarity).
CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD⁺ + H₂O = N-succinyl-L-glutamate + NADH.
PATHWAY: Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CR628336; CAH12824.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_123990.1; -.

3D structure databases

ModBase

Q5X4K4.

Enzyme and pathway databases

BioCyc

LPNE297246:LPP1672-MON; -.

Organism-specific databases

LegioList

lpp1672; -.

Ontologies

GO:0019544;	Biological process: arginine catabolic process to glutamate (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01174; -; 1.
PBIL [Tree]

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR017649; SuccinylGlu_semiald_DH_AstD.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

Q5X4K4.

Genome annotation databases

GeneID

3117549; -.

GenomeReviews

CR628336_GR; lpp1672.

KEGG

lpp:lpp1672; -.

Phylogenomic databases

HOGENOM

Q5X4K4; -.

Genome annotation databases

CMR

Q5X4K4; lpp1672.

Other

ProtoNet

Q5X4K4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Arginine metabolism; Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 495`	`495`	`N-succinylglutamate 5-semialdehyde dehydrogenase.`	`PRO_0000262406`
`NP_BIND`	`228 233`	`6`	`NAD (By similarity).`
`ACT_SITE`	`251 251`		`By similarity.`
`ACT_SITE`	`285 285`		`By similarity.`

Sequence information

Length: 495 AA [This is the length of the unprocessed precursor]

Molecular weight: 54541 Da [This is the MW of the unprocessed precursor]

CRC64: 13E21F1842F6FC53 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSKLQIIQSK GQYINGEWIK GNGLILESTN PASGTLLWQG NNATDEEITH ACYIAHCALK 

        70         80         90        100        110        120 
SWANTSFEER ARYTIAFVEQ VEKNRDQLAR LISLETGKPL WESQTEVSSV IGKVNLSIQA 

       130        140        150        160        170        180 
YQERTWPKQT ETAEANACLR FKPHGVVVVL GAFNFPAHLS NGHIVPALLA GNTVLYKPSE 

       190        200        210        220        230        240 
HTPAVAELII QCWHNSGLPP GVINCLQGNA NCGNTLLSQD IQGVYFTGSY ATGLRIHQQF 

       250        260        270        280        290        300 
CNRPEVILAL EMGGNNPLVI DEVKDINAAV YHTMLSTMIT AGQRCTCARR IIIPDSQTGD 

       310        320        330        340        350        360 
LFLERFAKAC KLMRIGSFDS QPEPFIGPVI NHVQALKHLH AQKQLIEIGG EIILPMSLLV 

       370        380        390        400        410        420 
EYTGLISPGI IDMTRAKNPP DEEIFAPFAQ IYRYNHFDEA IQLANQTRYG LSAGLLSDNK 

       430        440        450        460        470        480 
DHYLQFYQHI RAGLINWNRP TTGAASSLPF GGVGCSGNHR PSAYFAADYC AYPVASMEQP 

       490 
LLTTPAQRLP GLVLE

Q5X4K4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools