ID   CYSH_BACSK              Reviewed;         241 AA.
AC   Q5WKF5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   04-NOV-2008, entry version 29.
DE   RecName: Full=Phosphoadenosine phosphosulfate reductase;
DE            EC=1.8.4.8;
DE   AltName: Full=PAPS reductase, thioredoxin dependent;
DE   AltName: Full=PAdoPS reductase;
DE   AltName: Full=3'-phosphoadenylylsulfate reductase;
DE   AltName: Full=PAPS sulfotransferase;
GN   Name=cysH; OrderedLocusNames=ABC0611;
OS   Bacillus clausii (strain KSM-K16).
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=66692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii
RT   KSM-K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of activated sulfate into sulfite (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + sulfite +
CC       thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
CC   -!- PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite
CC       from sulfate: step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the PAPS reductase family. CysH subfamily.
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DR   EMBL; AP006627; BAD63150.1; -; Genomic_DNA.
DR   RefSeq; YP_174111.1; -.
DR   GeneID; 3204683; -.
DR   GenomeReviews; AP006627_GR; ABC0611.
DR   KEGG; bcl:ABC0611; -.
DR   NMPDR; fig|66692.3.peg.610; -.
DR   HOGENOM; Q5WKF5; -.
DR   BioCyc; BCLA66692:ABC0611-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0004604; F:phosphoadenylyl-sulfate reductase (thioredo...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0019379; P:sulfate assimilation, phosphoadenylyl sulfa...; IEA:HAMAP.
DR   HAMAP; MF_00063; -; 1.
DR   InterPro; IPR011798; APS_reductase.
DR   InterPro; IPR004511; CysH.
DR   InterPro; IPR002500; PAPS_reduct.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Gene3D; G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
DR   Pfam; PF01507; PAPS_reduct; 1.
DR   TIGRFAMs; TIGR02055; APS_reductase; 1.
DR   TIGRFAMs; TIGR00434; cysH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Oxidoreductase.
FT   CHAIN         1    241       Phosphoadenosine phosphosulfate
FT                                reductase.
FT                                /FTId=PRO_1000075070.
SQ   SEQUENCE   241 AA;  28151 MW;  672C682B65E037A3 CRC64;
     MAYVFEQMEA TDYEKVNTKL KNRDSLDILR WANQTYGEKL VYACSFGAEA MVLLDLLSKI
     QKEAHILFLD TDFHFAETYE LIERVKERYP TFRINMAKPA LSPEEQAERY GDELWLKNPD
     QCCQIRKLDV LARELEPYDA WLSGLRREQS PTRANTEFVN QDKRFKKVKV CPLIHWTEEE
     IWMYIKLHQL PYNELHDQHY PSIGCTYCTK AVMPGEDARS GRWAGTGKTE CGLHAPTKGD
     S
//