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UniProtKB/Swiss-Prot entry Q5WDH8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX2_BACSK
Primary accession number Q5WDH8
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on November 23, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 27)
Name and origin of the protein
Protein name Histidinol dehydrogenase 2
Synonyms HDH 2
EC 1.1.1.23
Gene name
Name: hisD2
OrderedLocusNames: ABC3048
From
Bacillus clausii (strain KSM-K16) [TaxID: 66692] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.;
"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16.";
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AP006627; BAD65582.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_176543.1; -.
3D structure databases
ModBase Q5WDH8.
Enzyme and pathway databases
BioCyc BCLA66692:ABC3048-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q5WDH8.
Genome annotation databases
GeneID 3204579; -.
GenomeReviews AP006627_GR; ABC3048.
KEGG bcl:ABC3048; -.
NMPDR fig|66692.3.peg.2958; -.
Phylogenomic databases
HOGENOM Q5WDH8; -.
Genome annotation databases
CMR Q5WDH8; ABC3048.
Other
ProtoNet Q5WDH8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Histidinol dehydrogenase 2. PRO_0000135725
ACT_SITE   321   321        Proton acceptor (By similarity). 
ACT_SITE   322   322        Proton acceptor (By similarity). 
METAL   253   253        Zinc (By similarity). 
METAL   256   256        Zinc (By similarity). 
METAL   355   355        Zinc (By similarity). 
METAL   414   414        Zinc (By similarity). 
BINDING   123   123        NAD (By similarity). 
BINDING   185   185        NAD (By similarity). 
BINDING   208   208        NAD (By similarity). 
BINDING   231   231        Substrate (By similarity). 
BINDING   253   253        Substrate (By similarity). 
BINDING   256   256        Substrate (By similarity). 
BINDING   322   322        Substrate (By similarity). 
BINDING   355   355        Substrate (By similarity). 
BINDING   409   409        Substrate (By similarity). 
BINDING   414   414        Substrate (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 44989 Da [This is the MW of the unprocessed precursor] CRC64: 071216AAFCD82413 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKIIELKEGE AVSLKRSGLH GSEAEIATVN TIIETVKKEG DQALVDYTQQ FDGVELTDLC 

        70         80         90        100        110        120 
VTKAELDNAY RHIDQPVLAA IRQAIANVRA FHEQQKAKSW FQTAPDGTIL GQRVTPLDAV 

       130        140        150        160        170        180 
GVYVPGGKAA YPSSIIMNVV PAQVAGVKDI SMVSPSGKNG TLPPAVLATA AELGVHTIYK 

       190        200        210        220        230        240 
LGGAQAVAAL AYGTETVRPV DKITGPGNKY VALAKRAVFG DVAIDMIAGP SEICVLADEK 

       250        260        270        280        290        300 
ANPAYVAADL LSQAEHDEDA TAVLVTPSRK LAEAVQQETA RQLATLPRKE IAGRALEQFG 

       310        320        330        340        350        360 
ALYVTASLAQ AIEVVNQLAP EHLEIATEEP LALLGRVKHA GAIFLGSYSA EPVGDYFAGP 

       370        380        390        400        410        420 
NHVLPTNGTA RFASPLSVDD FVKKSSIISY SKTALAENGK AITELARLEG LEAHARAIDI 


RLEDM
Q5WDH8 in FASTA format

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