[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.; "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).
CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH₃ + NADP⁺ = guanosine 5'-phosphate + NADPH.
SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP006627; BAD65750.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_176711.1; -.

3D structure databases

SMR

Q5WD10; 2-322.

ModBase

Q5WD10.

Enzyme and pathway databases

BioCyc

BCLA66692:ABC3216-MON; -.

Ontologies

GO:0003920;	Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163;	Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01511; -; 1.
PBIL [Tree]

InterPro

IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF00478; IMPDH; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF036500; GMP_red_Firmic; 1.

TIGRFAMs

TIGR01306; GMP_reduct_2; 1.

PROSITE

PS00487; IMP_DH_GMP_RED; 1.

BLOCKS

Q5WD10.

Genome annotation databases

GeneID

3204556; -.

GenomeReviews

AP006627_GR; ABC3216.

KEGG

bcl:ABC3216; -.

NMPDR

fig|66692.3.peg.3197; -.

Phylogenomic databases

HOGENOM

Q5WD10; -.

Genome annotation databases

CMR

Q5WD10; ABC3216.

Other

ProtoNet

Q5WD10.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 328`	`328`	`GMP reductase.`	`PRO_0000093750`
`NP_BIND`	`205 228`	`24`	`NADP (Potential).`
`ACT_SITE`	`176 176`		`Thioimidate intermediate (By similarity).`

Sequence information

Length: 328 AA [This is the length of the unprocessed precursor]

Molecular weight: 36286 Da [This is the MW of the unprocessed precursor]

CRC64: 2B8E4B033DBDA8FF [This is a checksum on the sequence]

        10         20         30         40         50         60 
MMENVFDYED IQLIPAKCIV GSRAECDTSV ELGGRTFKLP VVPANMQTII DENIARYLAE 

        70         80         90        100        110        120 
NDYFYIMHRF QPETRLAFVK DMHERGLYAS ISVGVKEEEY TFVQQLADQH VVPEYVTIDI 

       130        140        150        160        170        180 
AHGHSEAVIN MIRHIKTHLP DSFVIAGNVG TPEAVRELEH AGADATKVGI GPGKVCITKI 

       190        200        210        220        230        240 
KTGFGTGGWQ LAALRWCAKA ASKPIIADGG IRTHGDIAKS VRFGATMVMI GSLFAGHEES 

       250        260        270        280        290        300 
PGDTIEKDGK LYKEYFGSAS EYQKGERKNV EGKKMYVEHK GSLAETLLEM EQDLQSSISY 

       310        320 
AGGKRLDAIR NVDYVVVKNS IFNGDKIY

Q5WD10 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools