[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Liver; NIH - Zebrafish Gene Collection (ZGC) project; Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O₂ = 2-amino-3-carboxymuconate semialdehyde.
COFACTOR: Fe(2+) ion (By similarity).
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 3/3 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the 3-HAO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC085560; AAH85560.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001007391.1; -.

UniGene

Dr.37102

3D structure databases

ModBase

Q5U3F8.

Organism-specific databases

ZFIN

ZDB-GENE-041114-89; zgc:103585.

Family and domain databases

InterPro

IPR010329; 3hydroanth_dOase.
IPR016700; 3hydroanth_dOase_met.
Graphical view of domain structure.

Pfam

PF06052; 3-HAO; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF017681; 3hydroanth_dOase_animal; 1.

TIGRFAMs

TIGR03037; anthran_nbaC; 1.

BLOCKS

Q5U3F8.

Genome annotation databases

Ensembl

ENSDARG00000005928; Danio rerio. [Contig view]

GeneID

492518; -.

KEGG

dre:492518; -.

Phylogenomic databases

HOGENOM

Q5U3F8; -.

HOVERGEN

Q5U3F8; -.

Other

ProtoNet

Q5U3F8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 287`	`287`	`3-hydroxyanthranilate 3,4-dioxygenase.`	`PRO_0000245466`
`METAL`	`50 50`		`Iron; catalytic (By similarity).`
`METAL`	`56 56`		`Iron; catalytic (By similarity).`
`METAL`	`94 94`		`Iron; catalytic (By similarity).`
`BINDING`	`46 46`		`Dioxygen (By similarity).`
`BINDING`	`56 56`		`Substrate (By similarity).`
`BINDING`	`98 98`		`Substrate (By similarity).`
`BINDING`	`108 108`		`Substrate (By similarity).`

Sequence information

Length: 287 AA [This is the length of the unprocessed precursor]

Molecular weight: 33239 Da [This is the MW of the unprocessed precursor]

CRC64: A5A2B050B823F038 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTNQSLHVNI DKWIAENETS FLPPVCNKLM FFYQLNIMYV GGPNVRKDYH IEEGEELFYQ 

        70         80         90        100        110        120 
VRGDMVLKVI ENGKHKDVHI REGEMFLLPA RIPHSPQRQA NTVGLVIERR RLSKETDGLR 

       130        140        150        160        170        180 
YFVANSTEVL FERWFYCENL GTQLVPIIKE FMDSKENETG KPDPANPIKP APYPLNTMNV 

       190        200        210        220        230        240 
MTPFSFREWV EKQKPVLASG CPVDMFGEQF ETETLLFGSG TSANKRRTDG WIWQLEGLSN 

       250        260        270        280 
VFMNGKEYSL TAGDCLLIFG ETEYKWQRSQ DCVALYVAQD PDRKRPY

Q5U3F8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools