[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Embryo; NIH - Xenopus Gene Collection (XGC) project; Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylted H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promotes their ubiquitination and degradation (By similarity).
CATALYTIC ACTIVITY: Protein N₆,N⁶-dimethyl-L-lysine + 2-oxoglutarate + O₂ = protein N⁶-methyl-L-lysine + succinate + formaldehyde + CO₂.
CATALYTIC ACTIVITY: Protein N⁶-methyl-L-lysine + 2-oxoglutarate + O₂ = protein L-lysine + succinate + formaldehyde + CO₂.
COFACTOR: Binds 1 Fe(2+) ion per subunit (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
DOMAIN: The JmjC domain mediates the demethylation activity (By similarity).
SIMILARITY: Belongs to the JHDM1 histone demethylase family.
SIMILARITY: Contains 1 CXXC-type zinc finger.
SIMILARITY: Contains 1 F-box domain.
SIMILARITY: Contains 1 JmjC domain.
SIMILARITY: Contains 3 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 PHD-type zinc finger.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC086264; AAH86264.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001011176.1; -.

UniGene

Str.11178

3D structure databases

SMR

Q5U263; 34-362.

ModBase

Q5U263.

Family and domain databases

InterPro

IPR001810; F-box.
IPR013129; TF_JmjC.
IPR003347; TF_JmjC_AAH.
IPR002857; Znf_CXXC.
IPR001965; Znf_PHD.
Graphical view of domain structure.

Pfam

PF00646; F-box; 1.
PF02373; JmjC; 1.
PF00628; PHD; 1.
PF02008; zf-CXXC; 1.
Pfam graphical view of domain structure.

SMART

SM00558; JmjC; 1.
SM00249; PHD; 1.
SMART graphical view of domain structure.

PROSITE

PS50181; FBOX; FALSE_NEG.
PS51184; JMJC; 1.
PS51058; ZF_CXXC; 1.
PS01359; ZF_PHD_1; 1.
PS50016; ZF_PHD_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q5U263.

Genome annotation databases

Ensembl

ENSXETG00000015793; Xenopus tropicalis. [Contig view]

GeneID

496596; -.

KEGG

xtr:496596; -.

Phylogenomic databases

HOVERGEN

Q5U263; -.

Other

ProtoNet

Q5U263.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Chromatin regulator; Dioxygenase; Iron; Leucine-rich repeat; Metal-binding; Nucleus; Oxidoreductase; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 1146`	`1146`	`JmjC domain-containing histone demethylation protein 1A.`	`PRO_0000226787`
`DOMAIN`	`146 314`	`169`	`JmjC.`
`DOMAIN`	`874 919`	`46`	`F-box.`
`REPEAT`	`984 1009`	`26`	`LRR 1.`
`REPEAT`	`1047 1075`	`29`	`LRR 2.`
`REPEAT`	`1079 1102`	`24`	`LRR 3.`
`ZN_FING`	`585 631`	`47`	`CXXC-type.`
`ZN_FING`	`638 699`	`62`	`PHD-type.`
`METAL`	`210 210`		`Iron; catalytic (By similarity).`
`METAL`	`212 212`		`Iron; catalytic (By similarity).`
`METAL`	`282 282`		`Iron; catalytic (By similarity).`
`BINDING`	`207 207`		`Substrate (By similarity).`
`BINDING`	`227 227`		`Substrate (By similarity).`

Sequence information

Length: 1146 AA [This is the length of the unprocessed precursor]

Molecular weight: 131750 Da [This is the MW of the unprocessed precursor]

CRC64: C2812F2A5FD45816 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEEEQLRYSR RLRHTLRRRY EDDGISDDEI EGKRTFDLEE KLRSSKYNSN FITYMEGKDF 

        70         80         90        100        110        120 
NMKFIQEGGL RDPIIFTKSE GLGIKMPDPN FSVNDVKMFV GSRRVVDVMD VGTQKGIEMT 

       130        140        150        160        170        180 
MAQWAKYYET PEEEREKLYN VISLEFSHTK LENLVQRPTT VDQIDWVDNI WPRHLKDRQT 

       190        200        210        220        230        240 
ESTNVIQEMQ YPKVQKYCLM SVRGCYTDFH VDFGGTSVWY HILRGGKVFW LIPPTDQNLE 

       250        260        270        280        290        300 
LYENWLLSGK QGDVFLGDRV TECQRIELKQ GYTFVIPSGW IHAVYTPQDT LVFGGNFLHS 

       310        320        330        340        350        360 
FNIPMQLRIY SIEDRTRVPT KFRYPFYYEM CWYVLERYVY CMMRRSHLTK EFQRESLSID 

       370        380        390        400        410        420 
LELNGRQRPD TPSSSSSSSS SGLSSSSDND DSSDQDWEEE EGLRKRERDR CRVERELQRK 

       430        440        450        460        470        480 
RNRDRQQRDQ ERDRHGRTER IIIHTLPASL RPLTPPPSLP LPTPDSPPST SPFLTWFEVE 

       490        500        510        520        530        540 
GLRCLVLKLE SLPPLKKCLP DGIHDPEALI FDIKRLLEDH AHDPPELALT GVPIIQWPKR 

       550        560        570        580        590        600 
SQYKVHLRPK IQFTKPHTMR PASRHSTAPP RTSGTPSGTT ASSGARRRRV RCRKCQACVQ 

       610        620        630        640        650        660 
RECGTCHYCK DMKKFGGPGR MKQSCVLRQC LAPRLPHSVT CALCGEVDQT NDTQDFERKL 

       670        680        690        700        710        720 
MECSVCNEIV HPGCLEMDGE GLLSDELPNY WECPKCYEGQ KHTVEANHDR ILLHSKRKAA 

       730        740        750        760        770        780 
DNYESSHYYP AKVLRPPLGQ SPPSPPLLLL PPSPSSAPPT PPSAQTQVPL ASREERAKRR 

       790        800        810        820        830        840 
QLAREKENHP TGCDQSEGDR LRLRGPYLTV TLQRPPKELS STSIVPKLQA ITPNPRQPIR 

       850        860        870        880        890        900 
AAPLHQDEER EEEEEEEEEE EETENVMLGQ RKDSTSMQKD VWLSVFHYLT HEELCICMRV 

       910        920        930        940        950        960 
CKAWYKWGCD KRLWSRIDVS RCKSLVPQAL SGIIKRQPIY LDLSWTNVSK KQLIWLINRL 

       970        980        990       1000       1010       1020 
PGLKDLILAG CTWSAVSALA SCSCPLLRTL DLRWTVGIKD TQIRDLLTPA SDKSGHDSRS 

      1030       1040       1050       1060       1070       1080 
KLRLLTDLRL SGLDISDVTL RLIIRHCPLL SKLDLSHCPL LSDQSVNLLT AVGSSTRGTL 

      1090       1100       1110       1120       1130       1140 
THIHLAGCKG VTDESLLYLR RATNLSLIDL HGCKQVTRGA CEEFISDLSV STLYCLSDDK 


LIQRIS

Q5U263 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools