[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=Tuebingen; The Danio rerio sequencing project at the Sanger Institute; Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-288. NIH - Zebrafish Gene Collection (ZGC) project; Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AL929003; CAI21008.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC124544; AAI24545.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001038403.1; -.

UniGene

Dr.81533

3D structure databases

ModBase

Q5SPD7.

Organism-specific databases

ZFIN

ZDB-GENE-041014-244; pycrl.

Gene expression databases

ArrayExpress

Q5SPD7; -.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGR00112; proC; 1.

PS00521; P5CR; 1.

Genome annotation databases

Ensembl

ENSDARG00000015236; Danio rerio. [Contig view]

GeneID

560682; -.

KEGG

dre:560682; -.

Phylogenomic databases

HOGENOM

Q5SPD7; -.

HOVERGEN

Q5SPD7; -.

Other

ProtoNet

Q5SPD7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 288`	`288`		`Pyrroline-5-carboxylate reductase 3.`	`PRO_0000324565`

Sequence information

Length: 288 AA [This is the length of the unprocessed precursor]

Molecular weight: 29922 Da [This is the MW of the unprocessed precursor]

CRC64: 31A523F549C35D60 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSLSGASDKT SDSPDVFQIK IGFIGAGNMA FGVAQGIIAS GKVPPSNIII SAPSMNNLPR 

        70         80         90        100        110        120 
FKEKGVSVTH SNHEVVGGSR LIFLAVKPHI IPQVLKEISQ EVTKEHIIVS MAAGITIATL 

       130        140        150        160        170        180 
EELLPAGTHV IRIMPNLPCM LLEGALLLSC GSHAGEQEET LLKTLLGPCG LVEFGPESWI 

       190        200        210        220        230        240 
DAHVGLSGSG VAFVYVFAEA LADGAVKMGM PSTLARRIAA QTILGAGVLL RDSGKLPAEL 

       250        260        270        280 
KAEVCTPGGT TIHGIHALEK GGFRAAAIGA VEAASERARE LGNKQKKN

Q5SPD7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools