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UniProtKB/Swiss-Prot entry Q5RBE8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LOX15_PONAB
Primary accession number Q5RBE8
Secondary accession numbers None
Integrated into Swiss-Prot on March 1, 2005
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 32)
Name and origin of the protein
Protein name Arachidonate 15-lipoxygenase
Synonyms 15-LOX
EC 1.13.11.33
Arachidonate omega-6 lipoxygenase
Gene name
Name: ALOX15
From
Pongo abelii (Sumatran orangutan) [TaxID: 9601] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR858703; CAH90912.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
SMR Q5RBE8; 1-661, 2-662.
ModBase Q5RBE8.
Family and domain databases
InterPro IPR000907; LipOase.
IPR013819; LipOase_C.
IPR001024; LipOase_LH2.
IPR001885; LipOase_mml.
Graphical view of domain structure.
Gene3D G3DSA:2.60.60.20; Lipase_LipOase; 1.
PANTHER PTHR11771; LipOase; 1.
Pfam PF00305; Lipoxygenase; 1.
PF01477; PLAT; 1.
Pfam graphical view of domain structure.
PRINTS PR00087; LIPOXYGENASE.
PR00467; MAMLPOXGNASE.
SMART SM00308; LH2; 1.
SMART graphical view of domain structure.
PROSITE PS00711; LIPOXYGENASE_1; 1.
PS00081; LIPOXYGENASE_2; 1.
PS51393; LIPOXYGENASE_3; 1.
PS50095; PLAT; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q5RBE8.
Phylogenomic databases
HOVERGEN Q5RBE8; -.
Other
ProtoNet Q5RBE8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Dioxygenase; Iron; Leukotriene biosynthesis; Metal-binding; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   662  661     Arachidonate 15-lipoxygenase. PRO_0000220698
DOMAIN   2   114  113     PLAT. 
DOMAIN   115   662  548     Lipoxygenase. 
METAL   360   360        Iron; catalytic (By similarity). 
METAL   365   365        Iron; catalytic (By similarity). 
METAL   540   540        Iron; catalytic (By similarity). 
METAL   662   662        Iron; via carboxylate; catalytic (By similarity). 
Sequence information
Length: 662 AA [This is the length of the unprocessed precursor] Molecular weight: 74633 Da [This is the MW of the unprocessed precursor] CRC64: 375A826C56D9EEE6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGLYRIRVST GASLYAGSNN QVQLWLVGQH GEAALGTRLW PARGKETELK VEVPEYLGPL 

        70         80         90        100        110        120 
LFVKLRKRHL LTDDAWFCNW ISVQGPGAGD EVRFPCYRWV EGNGVLSLPE GTGRTVGDDP 

       130        140        150        160        170        180 
QGLFQKHREE ELEERRKLYR WGNWKDGLIL NVAGAKLCDL PVDERFLEDK RVDFEVSLAK 

       190        200        210        220        230        240 
GLADLAIKDS LNVLTCWKDL DDFNRIFWCG QSKLAERVRD SWKEDALFGY QFLNGANPVV 

       250        260        270        280        290        300 
LRRSVHLPAR LVFPPGMEEL QAQLEKELEG GTLFEADFSL LDGIKANVIL CSQQHLAAPL 

       310        320        330        340        350        360 
VMLKLQPDGK LLPMVIQLQL PSTGSPPPPL FLPTDPPMAW LLAKCWVRSS DFQLHELQSH 

       370        380        390        400        410        420 
LLRGHLMAEV IVVATMRCLP SIHPIFKLII PHLRYTLEIN VRARTGLVSD MGIFDQIMST 

       430        440        450        460        470        480 
GGGGHVQLLK QAGAFLTYSS FCPPDDLADR GLLGVKSSFY AQDALRLWEI IYRYVEGIVS 

       490        500        510        520        530        540 
LHYKTDVAVK DDPELQTWCR EITEIGLQGA QDRGFPVSLQ SRDQVCHFVT MCIFTCTGQH 

       550        560        570        580        590        600 
ASVHLGQLDW YSWVPNAPCT MRLPPPTTKD ATLETVMATL PNFHQASLQM SITWQLGRRQ 

       610        620        630        640        650        660 
PVMVAVGQHE EEYFSGPEPK AVLKKFREEL AALDKEIEIR NAKLDMPYEY LRPSIVENSV 


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Q5RBE8 in FASTA format

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