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UniProtKB/Swiss-Prot entry Q5R7B3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UGDH_PONAB
Primary accession number Q5R7B3
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on December 21, 2004 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 27)
Name and origin of the protein
Protein name UDP-glucose 6-dehydrogenase
Synonyms UDP-Glc dehydrogenase
UDP-GlcDH
UDPGDH
EC 1.1.1.22
Gene name
Name: UGDH
From
Pongo abelii (Sumatran orangutan) [TaxID: 9601] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR860205; CAH92347.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase Q5R7B3.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR017476; Nucleotide_sugar_DH.
IPR014027; UDP-Glc/GDP-Man_DHase_C.
IPR014026; UDP-Glc/GDP-Man_DHase_dimer.
IPR014028; UDP-Glc/GDP-Man_DHase_dimer-bd.
IPR001732; UDP-Glc/GDP-Man_DHase_N.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:3.40.50.1870; UDP-Glc/GDP-Man_DH_C; 1.
PANTHER PTHR11374; UDPG_MGDP_DH_Creg; 1.
Pfam PF00984; UDPG_MGDP_dh; 1.
PF03720; UDPG_MGDP_dh_C; 1.
PF03721; UDPG_MGDP_dh_N; 1.
Pfam graphical view of domain structure.
BLOCKS Q5R7B3.
Phylogenomic databases
HOVERGEN Q5R7B3; -.
Other
ProtoNet Q5R7B3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   494  494     UDP-glucose 6-dehydrogenase. PRO_0000317477
NP_BIND   6    23  18     NAD (By similarity). 
REGION   162   165  4     Substrate binding (By similarity). 
ACT_SITE   276   276        Nucleophile (By similarity). 
BINDING   36    36        NAD (By similarity). 
BINDING   41    41        NAD (By similarity). 
BINDING   93    93        NAD (By similarity). 
BINDING   131   131        NAD; via amide nitrogen (By similarity). 
BINDING   165   165        NAD (By similarity). 
BINDING   220   220        Substrate (By similarity). 
BINDING   273   273        Substrate; via amide nitrogen (By similarity). 
BINDING   279   279        NAD (By similarity). 
BINDING   339   339        Substrate (By similarity). 
BINDING   346   346        NAD (By similarity). 
MOD_RES   473   473        Phosphotyrosine (By similarity). 
Sequence information
Length: 494 AA [This is the length of the unprocessed precursor] Molecular weight: 55077 Da [This is the MW of the unprocessed precursor] CRC64: 9584347DAD728943 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFEIKKICCI GAGYVGGPTC SVIAHMRPEI RVTVVDVNES RINAWNSPTL PIYEPGLKEV 

        70         80         90        100        110        120 
VESCRGKNLF FSTNIDDAIK EADLVFISVN TPTKTYGMGK GRAADLKYIE ACARRIVQNS 

       130        140        150        160        170        180 
NGYKIVTEKS TVPVRAAESI RRIFDANTKP NLNLQVLSNP EFLAEGTAIK DLKNPDRVLI 

       190        200        210        220        230        240 
GGDETPEGQR AVQALCAVYE HWVPREKILT TNTWSSELSK LAANAFLAQR ISSINSISAL 

       250        260        270        280        290        300 
CEATGADVEE VATAIGMDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW 

       310        320        330        340        350        360 
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS IYISKYLMDE 

       370        380        390        400        410        420 
GAHLHIYDPK VPREQIVVDL SHPGVSEDDQ VSRLVTISKD PYEACDGAHA VVICTEWDMF 

       430        440        450        460        470        480 
KELDYERIHK KMLKPAFIFD GRRVLDGLHN ELQTIGFQIE TIGKKVSSKR IPYAPSGEIP 

       490 
KFSLQDPPNK KPKV
Q5R7B3 in FASTA format

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