[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain cortex; The German cDNA consortium; Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (By similarity).
CATALYTIC ACTIVITY: An S-prenyl-L-cysteine + O₂ + H₂O = a prenal + L-cysteine + H₂O₂.
COFACTOR: FAD (By similarity).
SUBCELLULAR LOCATION: Lysosome (By similarity).
SIMILARITY: Belongs to the prenylcysteine oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CR860270; CAH92412.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q5R748.

Family and domain databases

InterPro

IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR010795; Prenylcys_lyase.
IPR017046; Prenylcysteine_Oxase.
Graphical view of domain structure.

Pfam

PF07156; Prenylcys_lyase; 1.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF036292; Prenylcysteine_oxidase; 1.

BLOCKS

Q5R748.

Phylogenomic databases

HOVERGEN

Q5R748; -.

Other

ProtoNet

Q5R748.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Glycoprotein; Lysosome; Oxidoreductase; Signal; Ubl conjugation.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 27`	`27`	`Potential.`
`CHAIN`	`28 505`	`478`	`Prenylcysteine oxidase.`	`PRO_0000023301`
`CARBOHYD`	`196 196`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`323 323`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`353 353`		`N-linked (GlcNAc...) (Potential).`
`CROSSLNK`	`162 162`		`Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) (By similarity).`

Sequence information

Length: 505 AA [This is the length of the unprocessed precursor]

Molecular weight: 56752 Da [This is the MW of the unprocessed precursor]

CRC64: EA49ACA2F23D1313 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGRVVAELVS SLLGLWLLLC SCGCPEGAEL RAPPDKIAII GAGIGGTSAA YYLRQKFGKD 

        70         80         90        100        110        120 
VKIDLFEREE VGGRLATMMV QGQEYEAGGS VIHPLNLRMK RFVKDLGLST VQASGGLLGI 

       130        140        150        160        170        180 
YNGETLVFEE SNWFIINVIK LVWRYGFQSL RMHMWVEDVL DKFMRIYRYQ SHDYAFSSVE 

       190        200        210        220        230        240 
KLLHALGGDD FLGMLNRTLL ETLQKAGFSE KFLNEMIAPV MRVNYGQSTD INAFVGAVSL 

       250        260        270        280        290        300 
SCSDSGLWAV EGGNKLVCSG LLQASKSNLI SGSVMYIEEK TKTKHTGNPT KMYEVVYQIG 

       310        320        330        340        350        360 
TETRSDFYDI VLVATPLNRK MSNITFLNFD PPIEEFHQYY QHIVTTLVKG ELNTSIFSSR 

       370        380        390        400        410        420 
PIDKFGLNTV LTTDNSDLFI NSIGIVSSVR EKEDPEPSTD GTYVWKIFSQ ETLTKAQILK 

       430        440        450        460        470        480 
LFLSYDYAVK KPWLAYPHYK PPEKCPSIIL HDRLYYLNGI ECAASAMEMS AIAAHNAALL 

       490        500 
AYHRWNRHTD MIDQDGLYEK LKTEL

Q5R748 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools