[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain cortex; The German cDNA consortium; Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity).
CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2 .
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CR860576; CAH92701.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q5R6B5; 24-517.

ModBase

Q5R6B5.

Ontologies

GO:0005759;	Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

Q5R6B5.

Phylogenomic databases

HOVERGEN

Q5R6B5; -.

Other

ProtoNet

Q5R6B5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Mitochondrion; NAD; Oxidoreductase; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 17`	`17`	`Mitochondrion (Potential).`
`CHAIN`	`18 517`	`500`	`Aldehyde dehydrogenase X, mitochondrial.`	`PRO_0000271412`
`NP_BIND`	`262 267`	`6`	`NAD (By similarity).`
`ACT_SITE`	`285 285`		`Proton acceptor (By similarity).`
`ACT_SITE`	`319 319`		`Nucleophile (By similarity).`
`SITE`	`186 186`	`1`	`Transition state stabilizer (By similarity).`

Sequence information

Length: 517 AA [This is the length of the unprocessed precursor]

Molecular weight: 57261 Da [This is the MW of the unprocessed precursor]

CRC64: 105F47E5840D4229 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLRFLAPRLL SLQGRTARYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT 

        70         80         90        100        110        120 
TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNCLAD LVERDRVYLA 

       130        140        150        160        170        180 
SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKWHGKT IPMDGQHFCF TRHEPIGVCG 

       190        200        210        220        230        240 
QIIPWNFPLV MQGWKLAPAL ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG 

       250        260        270        280        290        300 
YGPTAGAAIA QHMDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM 

       310        320        330        340        350        360 
EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP 

       370        380        390        400        410        420 
QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP 

       430        440        450        460        470        480 
VQPLFKFKKM EEVIERANTT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT 

       490        500        510 
PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS

Q5R6B5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools