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UniProtKB/Swiss-Prot entry Q5QWY8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_IDILO
Primary accession number Q5QWY8
Secondary accession numbers None
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on January 4, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 27)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: IL0598
From
Idiomarina loihiensis [TaxID: 135577] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales; Idiomarinaceae; Idiomarina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=L2-TR / ATCC BAA-735 / DSM 15497;
DOI=10.1073/pnas.0407638102; PubMed=15596722 [NCBI, ExPASy, EBI, Israel, Japan]
Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y., Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S., Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S., Denery J., Aizawa S., Shibata S., Malahoff A., Alam M.;
"Genome sequence of the deep-sea gamma-proteobacterium Idiomarina loihiensis reveals amino acid fermentation as a source of carbon and energy.";
Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017340; AAV81439.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_154988.1; -.
3D structure databases
ModBase Q5QWY8.
Enzyme and pathway databases
BioCyc ILOI283942:IL0598-MON; -.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS Q5QWY8.
Genome annotation databases
GeneID 3174600; -.
GenomeReviews AE017340_GR; IL0598.
KEGG ilo:IL0598; -.
NMPDR fig|283942.3.peg.977; -.
Phylogenomic databases
HOGENOM Q5QWY8; -.
Genome annotation databases
CMR Q5QWY8; IL0598.
Other
ProtoNet Q5QWY8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   562  562     NAD-dependent malic enzyme. PRO_0000160219
ACT_SITE   101   101        Proton donor (By similarity). 
ACT_SITE   172   172        Proton acceptor (By similarity). 
METAL   243   243        Divalent metal cation (By similarity). 
METAL   244   244        Divalent metal cation (By similarity). 
METAL   267   267        Divalent metal cation (By similarity). 
BINDING   154   154        NAD (By similarity). 
BINDING   267   267        NAD (By similarity). 
BINDING   415   415        NAD (By similarity). 
SITE   267   267  1     Important for activity (By similarity). 
Sequence information
Length: 562 AA [This is the length of the unprocessed precursor] Molecular weight: 62784 Da [This is the MW of the unprocessed precursor] CRC64: 2BD4C66FC61FFCB2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPQTQRPLYI PYSGPNLLET PLLNKGSAFS KEERAAFNLT GLLPPRYESI EEQAERAYMQ 

        70         80         90        100        110        120 
YRSFETPINK HIYLRAIQDN NETLFYRLLT DHLEEMMPII YTPTVGDACE KFSDIYRSSR 

       130        140        150        160        170        180 
GLFISYSERD QIDDILRNAT KQKVKVIVVT DGERILGLGD QGIGGMGIPI GKLSLYTACG 

       190        200        210        220        230        240 
GISPAYTLPV MLDVGTNNEK LLEDPMYMGA RHKRIEQDEY DEFLDKFIKA VTRRWPGVML 

       250        260        270        280        290        300 
QFEDFAQPNA MPLLRRYRDE VCCFNDDIQG TASVTVGTLL AACRQKGKKL SEQKVVFVGA 

       310        320        330        340        350        360 
GSAGCGIAEQ IMIQMTAEGL TEEQAKRQIF MVDRFGLVMD TMDGLRDFQQ ALAQKTSDLN 

       370        380        390        400        410        420 
AWEYSGEYPS LLDVMHCAEP DILIGVSGQA GLFTEQVIST MAKNVERPII FPLSNPSKHV 

       430        440        450        460        470        480 
EAHPADVLKW SEGKAIVATG SPFGEVEYDG RIYPIAQCNN SYIFPGIGLG VLSVKSERVS 

       490        500        510        520        530        540 
DEMLRVASKT LANASPSANG KGEALLPAFN DLTQLSKDIA FAVGKVAQQE GLALEIDDDT 

       550        560 
LRERIDNNFW KPEYRFYKRV SI
Q5QWY8 in FASTA format

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